The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure

M Packer - Journal of the American College of Cardiology, 1992 - Elsevier
heart failure primarily as a hemodynamic disorder. When we learn about the pathophysiology
of heart failure… ihe treatment of heart failure. WC think in terms ofcardiac output. pulmonary …

Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure

GW Moe, P Armstrong - Cardiovascular research, 1999 - academic.oup.com
… to develop cardiac hypertrophy during the evolution of heart failure. Although the reasons …
for studying the mechanisms of the rapid progression of heart failure and partly prompted …

Mechanisms and models in heart failure: a combinatorial approach

DL Mann - Circulation, 1999 - Am Heart Assoc
progression and the many insights that neurohormonal models have provided in terms of drug
development for heart failure… completely explain disease progression in heart failure. This …

Role of cell death in the progression of heart failure

GW Moe, J Marín-García - Heart failure reviews, 2016 - Springer
… [61] have previously reported that early and continuous activation of myocardial apoptosis
and pro-apoptotic factors may be an important mechanism that contributes to the progression

The cellular pathophysiology of progression to heart failure

LE Wagoner, RA Walsh - Current opinion in cardiology, 1996 - journals.lww.com
… end-stage cardiomyopathic congestive heart failure. Animal models of heart failure such as
… to our understanding of the mechanisms of progression to heart failure. A new animal model …

A possible mechanism for the progression of chronic renal disease and congestive heart failure

RN Re - Journal of the American Society of Hypertension, 2015 - Elsevier
… This then suggests that certain progressive degenerative cardiovascular disorders such
as forms of chronic renal insufficiency and systolic congestive heart failure result from …

Progression from Hypertension to Heart Failure Mechanisms and Management

JGF Cleland - Cardiology, 1999 - karger.com
Patients with hypertension are at increased risk of developing heart failure (HF), but the
mechanisms by which hypertension leads to HF have not been clarified [although left ventricular …

Metabolic mechanisms in heart failure

H Ashrafian, MP Frenneaux, LH Opie - Circulation, 2007 - Am Heart Assoc
progression of heart failure may thus be postulated. Accordingly, we review the cellular
mechanisms and pathophysiology of altered metabolism and insulin resistance in heart failure. It …

Mechanisms and models in heart failure: the biomechanical model and beyond

DL Mann, MR Bristow - Circulation, 2005 - Am Heart Assoc
… in terms of drug development for heart failure, there is increasing clinical evidence to …
progression in heart failure. Our current medical therapies for heart failure will stabilize heart failure

Risk of heart failure progression in patients with reduced ejection fraction: mechanisms and therapeutic options

E Gronda, E Vanoli, S Sacchi, G Grassi… - Heart Failure …, 2020 - Springer
heart failure. Schematic representation of the cascade of pathophysiologic events underlying
the progression of heart failure… , then, is a marker of the heart failure status. ANS: autonomic …