… PARPis resistance. This review aims to analyze the mechanisms underlying PARPis resistance
… potential therapeutic strategies to overcome these processes of resistance in the future. …

… In addition to the induction of expression through this adaptive mechanism of resistance,
ligands can be intrinsically expressed due to genetic rearrangements in the tumor cell. This is …

… system; therefore, biomarkers of response and resistance to anti-CTLA4 therapy may differ
from other immune checkpoint inhibitors that have different mechanisms of action (MOAs) 15 . …

… complication of treatment with checkpoint inhibitors. While the clinical … exact mechanisms
of irAEs are not well understood [14, 15]. In this review, the current knowledge of mechanisms …

… or progress and become immunotherapy-resistant tumors [14]. Impaired MHC class I antigen
processing has been proposed as a mechanism of acquired resistance to ICIs. For instance…

… to contribute to immunotherapeutic resistance in some epithelial … 1 (PD-1) checkpoint
inhibition is deployed for programmed cell … This suggests that the efficacy of checkpoint inhibitors …

… been reported to be upregulated in many other human cancers [17] by two general mechanisms,
namely innate immune resistance and adaptive immune resistance. By innate immune …

… a single therapy due to the complexity of drug resistance mechanisms. Improving the current
understanding of mechanisms limiting cancer immunotherapy may aid in the discovery of …

… developed acquired resistance after initial responses … mechanisms largely remain unknown.
In this review, we will focus on documented mechanisms of primary and acquired resistance …

… checkpoint inhibitors improve the outcomes of patients in only a subset of them and the
molecular mechanisms … In this review, we discuss the latest progress regarding mechanisms by …