… Since the discovery that non-small cell lung cancer (NSCLC) is driven by epidermal growth
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg., …

… EGFR-TKIs resistance mechanisms in NSCLC models and patients published in peer-reviewed
scientific journals and listed in PubMed since the discovery of EGFR… EGFR TKIs requires …

… reported in the past few years include secondary mutation of the EGFR gene, amplification
… resistance. This review focuses on these mechanisms of acquired resistance to EGFR-TKIs …

… mechanisms which contribute towards EGFR TKI resistance in NSCLC. Several therapeutic
approaches to overcome TKI resistance … and third generation EGFR TKI inhibitors and cMET …

… EGFR tyrosine kinase inhibitors (TKIs) competitively inhibit ATP with cleft of the kinase … the
mechanism of EGFR-TKI tolerance and present treatment strategies to overcome resistance. …

… In particular, we focused on the EGFR TKI-based treatments in the first-line setting, after
progression due to T790M-positive or negative tumors and in patients who become resistant to …

… However, acquired therapeutic resistance to these agents … mechanisms of EGFR TKI
resistance in an effort to design rational strategies to overcome this acquired drug resistance. …

… To attenuate the effects that EGFR pathways take on cancers, EGFR TKIs that bind the …
mechanism and summarize the existing bypass tracks contributing to TKI resistance via EGFR-…

… EGFR-TKIs depends on the type of EGFR mutations, and the development of resistance
to such TKI … the literature about molecular mechanisms of EGFR-TKI resistance in EGFR-mutated …

… start a battle against EGFR-TKI resistance. Challenging as it … the major mechanisms of
acquired resistance to EGFR-TKIs, … drugs in accordance with each mechanism, in the hope of …