Mechanistic advances in osteoporosis and antiosteoporosis therapies

H Wang, Y Luo, H Wang, F Li, F Yu, L Ye - MedComm, 2023 - Wiley Online Library
… to both mechanistically and clinically demonstrate the state-of-art advances in osteoporosis.
… with the mechanistical advances and clinical knowledge of osteoporosis and furthermore …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
… and clinical implications of osteoporosis have identified novel … for osteoporosis management
in the future. Here, we review the etiology of osteoporosis and the molecular mechanism of …

[HTML][HTML] Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review

NR Elahmer, SK Wong, N Mohamed, E Alias, KY Chin… - Biomedicines, 2024 - mdpi.com
… Contributing factors to secondary osteoporosis encompass … to consolidate mechanistic
insights into osteoporosis and the … the intricate mechanistic underpinnings of osteoporosis, …

Osteoporosis: mechanism, molecular target and current status on drug development

H Li, Z Xiao, LD Quarles, W Li - Current medicinal chemistry, 2021 - ingentaconnect.com
… the molecular mechanisms of osteoporosis, current drugs for osteoporosis treatment, and …
for treating osteoporosis are categorized into either anti-resorptive drugs or anabolic drugs. Anti

Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
osteoporosis. In this review, we summarize novel mechanisms involved in the pathological
process of osteoporosis, … pathological mechanism, we found promising drugs for osteoporosis

Advances in mechanobiological pharmacokinetic-pharmacodynamic models of osteoporosis treatment–Pathways to optimise and exploit existing therapies

P Pivonka, JL Calvo-Gallego, S Schmidt… - Bone, 2024 - Elsevier
… commenced, while the other mechanism was related to the secondary mineralisation of the
existing bone matrix. It was found that the former mechanism is quite unlikely to significantly …

Cathepsin K inhibition: a new mechanism for the treatment of osteoporosis

LT Duong, AT Leung, B Langdahl - Calcified tissue international, 2016 - Springer
… Recent advancements in the understanding of skeletal biology have brought new … strength
in osteoporotic patients. In this review, we focus on a new class of drugs, to treat osteoporosis, …

[HTML][HTML] Emerging Roles of Natural Compounds in Osteoporosis: Regulation, Molecular Mechanisms and Bone Regeneration

S Ilyas, J Lee, D Lee - Pharmaceuticals, 2024 - mdpi.com
… Signaling pathways are the main conductor in the intricate mechanism of bone remodeling,
balancing bone formation/resorption. Among these, the Wnt/β-catenin, BMP/Smad, MAPK …

Therapeutic and mechanistic approaches of Tridax procumbens flavonoids for the treatment of osteoporosis

MAA Al-Bari, S Hossain, U Mia… - Current drug …, 2020 - ingentaconnect.com
… as anti-inflammatory, anti-anaemic and anti-diabetic actions. This review designed to focus
the systematic convention concerning the medicinal property and mechanismosteoporosis. It …

Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
… with low BMD and increased risks of osteoporotic fracture [119]. Mechanistically, these
SNPs are believed to increase osteoporosis susceptibility via influencing the binding affinity of …