… and clinical findings in patients with heart failure with preserved ejection fraction stratified by
study design: … Effects of candesartan in patients with chronic heart failure and preserved left-…

… This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP), and the
metabolism of natriuretic peptides in heart failure (HF) and providing additional mechanistic …

… the clinical course of patients with diabetes who have established heart failure. It is therefore
noteworthy that, in several observational studies, patients with chronic heart failure who had …

… pre-clinical and clinical studies. … studies indicate that acquired somatic mutations in
haematopoietic cells are associated with a markedly increased risk of coronary heart disease in …

… More than one-fourth of the cohort had a KCCQ score below 75, a threshold value that has
been used in clinical trials of established heart failure to denote at least a moderate burden of …

… toward greater success in AHFS clinical trials. Acute heart failure syndromes (AHFS) have
been defined as the gradual or rapid onset of signs or symptoms of heart failure (HF) requiring …

… development of cardiac dilation and contractile dysfunction, the hallmarks of heart failure. To
… that myocyte apoptosis may be a causal mechanism of heart failure, and they suggest that …

… Chronic heart failure is a syndrome of reduced cardiac output resulting from impaired ventricular
… Several phases 2 and 3 clinical trials conducted with Omecamtiv mecarbil to date are …

… Heart failure (HF) 9 is one of the leading causes of mortality and is associated … in patients
with chronic heart failure (CHF) and are associated with adverse outcome (3). The congestive …

… heart failure in precise mechanistic and/or clinical terms is that the clinical syndrome of heart
failure … 14 Second, clinical studies have shown that antagonizing neurohormones leads to …