[HTML][HTML] Mechanistic insight and clinical implications of ischemia/reperfusion injury post liver transplantation

J Liu, K Man - Cellular and molecular gastroenterology and …, 2023 - Elsevier
… Furthermore, mechanistic studies of living donor liver transplantation have elucidated … -for-size
graft injury. The mechanistic findings of hepatic ischemia/reperfusion injury have laid the …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
… The current review gives a brief outline of the pathophysiological mechanism of TBI and
various biochemical pathways involved in brain injury, pharmacological treatment approaches, …

Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury

H Khan, A Gupta, TG Singh, A Kaur - Pharmacological Reports, 2021 - Springer
… nature and mechanistic interventions of the leukotriene receptor modulations in ischemic
injury. In the pathophysiology of I/R injuries, LT has been found to play an important role. I/R …

New mechanistic insights, novel treatment paradigms, and clinical progress in cerebrovascular diseases

J Boltze, JA Aronowski, J Badaut… - Frontiers in Aging …, 2021 - frontiersin.org
… modifications in different brain structures at 12 months post-injury after a single impact. …
vascular loss post-TBI, new immature vessels occurred at the injury site 7 days after the injury. …

Mechanistic insights into posttraumatic syringomyelia based on a novel in vivo animal model

T Seki, MG Fehlings - Journal of Neurosurgery: Spine, 2008 - thejns.org
… and caudal to the injury site. The mechanism of cavity extension appears to be related in
part to tethering of the spinal cord by scarring and fibrosis at the site of injury, which limits cord …

Inflammation following traumatic brain injury in humans: insights from data-driven and mechanistic models into survival and death

A Abboud, Q Mi, A Puccio, D Okonkwo… - Frontiers in …, 2016 - frontiersin.org
… While further studies are needed in order to validate key predictions, the present study
may point to both novel mechanistic insights and clinically translational applications. …

[PDF][PDF] Translating mechanistic insight into therapy

J McCulloch - Restorative Neurology and Neuroscience, 2010 - Citeseer
… Lesion volumes were evaluated at 48 hours post-injury on cresyl violet-stained sections.
Results: At 48 hours after ischemia 41 to 48% (I/R-1 model) and 30% (I/R-2 model) of rats did …

Neuromuscular consequences of spinal cord injury: New mechanistic insights and clinical considerations

MIB Debenham, CK Franz, MJ Berger - Muscle & Nerve, 2024 - Wiley Online Library
… Spinal cord injuries (SCIs) can lead to partial paralysis and dysfunctions in muscles
below the injury. While … 20.1 ± 8.4 μs) from as little as 2 months post-injury up to 3 years56 …

Mechanisms and interventions on acute lower limb ischemia/reperfusion injury: a review and insights from cell to clinical investigations

P Apichartpiyakul, K Shinlapawittayatorn… - Annals of Vascular …, 2022 - Elsevier
… This review aims to highlight mechanistic insights on skeletal muscle ischemia/reperfusion
injury (IRI), a potentially life-threatening complication after acute lower limb ischemia. Lower …

Injury research in the genomic era

JP Cobb, GE O'Keefe - The Lancet, 2004 - thelancet.com
… We review the limitations in our present understanding of post-injury sepsis and organ
failure, discuss recent findings for genetic influences on the risk for post-traumatic sepsis, and …