[HTML][HTML] Comprehensive analysis of drugs to treat SARSCoV‑2 infection: Mechanistic insights into current COVID‑19 therapies

GM Nitulescu, H Paunescu… - International …, 2020 - spandidos-publications.com
… on hypotheses regarding the mechanism of transfer of SARS-CoV-2 from the respira-tory
tract to the intestines (34), which is manifested through faecal detection of SARS-CoV-2 RNA (…

Mechanistic insight into the protective and pathogenic immune-responses against SARS-CoV-2

PK Purbey, K Roy, S Gupta, MK Paul - Molecular Immunology, 2023 - Elsevier
… The infection cycle of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 1. …
Mechanistic insight into the immune-responses against SARS-CoV-2 during non-severe (…

A review of medicinal plants with antiviral activity available in Bangladesh and mechanistic insight into their bioactive metabolites on SARS-CoV-2, HIV and HBV

SC Bachar, K Mazumder, R Bachar, A Aktar… - Frontiers in …, 2021 - frontiersin.org
mechanistic insights into their bioactive components against three most hazardous viruses,
namely SARS-CoV-2… to inhibit multiple molecular targets of SARS-CoV-2 viral replication in a …

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2

M Arba, ST Wahyudi, DJ Brunt, N Paradis… - Computers in biology and …, 2021 - Elsevier
… been therefore approved for emergency use of treating SARS-CoV-2 virus [7]. … , its mechanism
of action is not completely understood [10,11]. This study aims to elucidate the mechanism

Mechanistic Insight into SARS-CoV-2 Mpro Inhibition by Organoselenides: The Ebselen Case Study

A Madabeni, PA Nogara, FB Omage, JBT Rocha… - Applied Sciences, 2021 - mdpi.com
… The main protease (M pro ) of SARS-CoV-2 is a current target … in-silico the molecular
mechanism by which ebselen (IUPAC: … For the first time, we report on a mechanistic investigation …

Mechanistic insight of SARS-CoV-2 infection using human hepatobiliary organoids

Y Zhao, X Ren, J Lu, M He, Z Liu, L Yi, M Huang… - Gut, 2023 - gut.bmj.com
SARS-CoV-2 and demonstrated ASGR1 as alternative functional receptors, providing insight
into SARS-CoV-… liver organoids, which may explain that SARS-CoV-2 viral load was higher …

[PDF][PDF] Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome

I Pablos, Y Machado, HCR de Jesus, Y Mohamud… - Cell reports, 2021 - cell.com
The main viral protease (3CL pro ) is indispensable for SARS-CoV-2 replication. We
delineate the human protein substrate landscape of 3CL pro by TAILS substrate-targeted N-…

[HTML][HTML] Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

G Kokic, HS Hillen, D Tegunov, C Dienemann… - Nature …, 2021 - nature.com
mechanistic insights should facilitate the quest for improved antivirals that target coronavirus
… Meanwhile, the mechanistic insights presented here may facilitate the search for …

Targeting SARS-CoV-2 main protease by teicoplanin: A mechanistic insight by docking, MM/GBSA and molecular dynamics simulation

F Azam, EEM Eid, A Almutairi - Journal of Molecular Structure, 2021 - Elsevier
… potential therapeutic efficacy against SARS-CoV-2 in vitro. Therefore, in this study, a
mechanistic insight of intermolecular interactions between teicoplanin and SARS-CoV-2 M Pro has …

[HTML][HTML] Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
… Gaining mechanistic insights into pathways elicited by SARS-CoV-2 infection could provide
… evidence strongly advocates that SARS-CoV-2 is entirely a unique pathologic entity (3). …