… Second, guided by this activation mechanism and Markov state … After identifying such a pocket
in SARS-CoV2 Nsp16, we show … based on mechanistic insights from Markov state models. …

… -2 has a significantly lower free energy than that of SARS-CoV, suggesting that SARS-CoV-…
than SARS-CoV. This provides insights into the evolution of SARS-CoV-2 because SARS-…

… CONCLUSIONS: This study aims to show the functional role of CQ and HCQ, as well as to
provide possible mechanistic insight on the role of iron on viral infection, iron starvation and its …

… Herein, we demonstrate SARS-CoV-2 helicase as a target of … Finally, we validate our in
vitro data in SARS-CoV-2 infected … effective antiviral drugs to combat SARS-CoV-2 infection. …

… In this work, we examined the genome sequence of SARS-CoV-2 VOCs and their
phylogenetic relationships with the other PANGOLIN lineages. The mutational landscape of WHO …

… the previous coronavirus epidemics (SARS-CoV and MERS-CoV). Sequencing of the
SARS-CoV-2 viral genome revealed a concordance rate of approximately 80% with SARS-CoV, its …

… SARS coronavirus (SARS-CoV), which caused about 8,000 infections and 800 deaths (3, 4).
Compared to SARS-CoV, many SARS-CoV-2 … The cell entry mechanism of SARS-CoV has …

… The membrane fusion mechanism of SARS-CoV-2 offers an … -like trimeric spike glycoproteins
of SARS-CoV-2 to the receptor … insights for targeting the membrane fusion mechanism for …

The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

… mechanistic insight into the role of specific host genes and viral strains in regulating
pathogenesis across species. In appropriately selected large population screens, highly penetrant …