[HTML][HTML] Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

H Rahimi, R Bell, EM Bouta, RW Wood, L Xing… - Arthritis Research & …, 2016 - Springer
biomarkers may be applied to aid in diagnosis of arthritic flare and to assess therapeutic
effectiveness. The mechanisticpotential of emerging lymphatic vessel biomarkers in RA. …

Mechanism-based biomarker discovery

A Antoranz, T Sakellaropoulos, J Saez-Rodriguez… - Drug discovery today, 2017 - Elsevier
… Despite significant efforts that have identified thousands of potential biomarkers, their translation
into clinical practice remains poor: less than two approvals per year across all diseases. …

[HTML][HTML] Earthworm toxicogenomics: a renewed genome-wide quest for novel biomarkers and mechanistic insights

P Gong, EJ Perkins - Applied Soil Ecology, 2016 - Elsevier
… , examine novel biomarkers discovered and mechanistic insights gained through …
Additional bioassays may be performed to validate the identified potential biomarker genes. …

Proteomics and metabolomics for mechanistic insights and biomarker discovery in cardiovascular disease

J Barallobre-Barreiro, YL Chung, M Mayr - Revista Española de Cardiología …, 2013 - Elsevier
In the last decade, proteomics and metabolomics have contributed substantially to our
understanding of cardiovascular diseases. The unbiased assessment of pathophysiological …

[HTML][HTML] Proteomics and lipidomics in inflammatory bowel disease research: from mechanistic insights to biomarker identification

B Titz, RM Gadaleta, G Lo Sasso, A Elamin… - International Journal of …, 2018 - mdpi.com
… further insights into IBD pathomechanisms and support the development of novel biomarker
… However, thus far, both these omics technologies have not exploited their full potential. The …

The cardiorenal syndrome: mechanistic insights and prognostication with soluble biomarkers

S Seliger - Current Cardiology Reports, 2020 - Springer
… have been proposed as a major mechanism accounting for decreased estimated glomerular
filtration … impairment and potentially acute renal failure requiring renal replacement therapy. …

[HTML][HTML] Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights

M Mayr, J Zhang, AS Greene, D Gutterman… - Molecular & Cellular …, 2006 - ASBMB
… role of proteomics in characterizing biomarkers and biosignatures for the … biomarker
development and lay out a vision for how this technology promises to facilitate distinct biomarker

[HTML][HTML] Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation

W You, B Shang, J Sun, X Liu, L Su… - Oncology …, 2020 - spandidos-publications.com
… In this review, a mechanism‑based interpretation of tumor PD‑L1 expression and other candidate
biomarkers … Directions for future biomarker development and the potential of combined …

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review

V Narayan, EW Thompson, B Demissei, JE Ho… - Journal of the American …, 2020 - jacc.org
… The purpose of this state-of-the-art review is to further our understanding of the potential
mechanisms underlying cancer and CVD by contextualizing pathways and biomarkers common …

Insight of nitric oxide signaling: A potential biomarker with multifaceted complex mechanism in colorectal carcinogenesis

P Mandal - Biochemical and biophysical research communications, 2018 - Elsevier
Colorectal carcinogenesis (CRC) is the most important health concerns throughout the World
as the tumour cells rapidly spread and abruptly grow in colon and rectum to further organs. …