Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

H Rahimi, R Bell, EM Bouta, RW Wood, L Xing… - Arthritis Research & …, 2016 - Springer
… In this review, we will: outline the current knowledge of lymphatic function as it relates to RA;
describe how contemporary lymphatic imaging methods reveal a central role for lymphatics

Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers

M Petkova, I Ferby, T Mäkinen - The Journal of Clinical …, 2024 - Am Soc Clin Investig
… of lymphatic vessels can result in serious health complications. Here, we discuss lymphatic
… as fluid-filled cysts or extensive infiltrative lymphatic vessel overgrowth, often associated with …

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

D Olmeda, D Cerezo-Wallis, E Castellano-Sanz… - Advanced Drug Delivery …, 2021 - Elsevier
… Although PET has limitations due to its high cost and poor resolution in animal models, it has
been successfully applied for detection and mechanistic characterization of lymph nodes in …

Biomechanical control of lymphatic vessel physiology and functions

V Angeli, HY Lim - Cellular & Molecular Immunology, 2023 - nature.com
imaging approaches in the past decade have led to the identification of specific lymphatic
been reported to alter lymphatic barrier function through a mechanism dependent upon Rac1-…

[HTML][HTML] Lymphatic function measurements influenced by contrast agent volume and body position

EM Bouta, C Blatter, TA Ruggieri, EFJ Meijer, LL Munn… - JCI insight, 2018 - ncbi.nlm.nih.gov
… Here we show how experimental parameters can dramatically affect the endpoints of NIRF
imaging, direct fluorescence imaging of lymphatic contraction, and DOCT. Mouse position …

Mechanisms of lymphatic metastasis

S Karaman, M Detmar - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
… in lymphatic biology; however, their impact was initially controversial, since it was unclear
whether this mechanism … has been used in its free form for lymphatic imaging in humans (78). …

Imaging leukocyte migration through afferent lymphatics

V Collado‐Diaz, JD Medina‐Sanchez… - Immunological …, 2022 - Wiley Online Library
… how time-lapse imaging has contributed to the current model of lymphatic trafficking and
the … Key mechanistic insights on lymphatic migration made by time-lapse imaging. (AB) An …

Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function

T Kassis, AB Kohan, MJ Weiler… - Journal of …, 2012 - spiedigitallibrary.org
… to fast our animal before an imaging experiment. This is also important since peristalsis is
thought to provide an extrinsic mechanism for driving lymph flow, 54 thus studies designed that …

Lymphatic malformations: genetics, mechanisms and therapeutic strategies

T Mäkinen, LM Boon, M Vikkula, K Alitalo - Circulation research, 2021 - Am Heart Assoc
… Here we discuss developmental lymphatic anomalies called lymphatic malformations and
complex lymphatic anomalies that manifest as localized or multifocal lesions of the lymphatic

Animal models for the molecular and mechanistic study of lymphatic biology and disease

WS Shin, SG Rockson - Annals of the New York Academy of …, 2008 - Wiley Online Library
… development and the diseases associated with lymphaticlymphatic vascular development,
and have provided insight into the pathophysiology of both inherited and acquired lymphatic