IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo

A Lavoie-Lamoureux, K Moran… - … of Physiology-Lung …, 2010 - journals.physiology.org
… We also compared the response of neutrophils isolated from animals affected with chronic …
IL-4-activated equine neutrophils share features described for human neutrophils, suggesting …

Equine neutrophils and their role in ischemia reperfusion injury and lung inflammation

SL Anderson, B Singh - Cell and Tissue Research, 2018 - Springer
… strong neutrophilic response. Here, we review basic equine neutrophil biology and explore
the role of neutrophils in … In addition, unique aspects of equine neutrophil biology have been …

Evaluation of lipopolysaccharide-induced activation of equine neutrophils

DJ Weiss, OA Evanson - American journal of veterinary research, 2002 - Am Vet Med Assoc
… Although the pathogenesis is complex, intravascularly activated neutrophils appear to be
major mediators of the adverse systemic effects associated with endotoxemia.General …

Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro

AP Foster, P Lees, FM Cunningham - Research in veterinary science, 1992 - Elsevier
equine neutrophils in vivo and in vitro. In this study the in vitro migratory response of equine
eosinophils and neutrophils … migration of both equine cosinophils and neutrophils, maximal …

Role of neutrophils in equine asthma

B Uberti, G Morán - Animal health research reviews, 2018 - cambridge.org
… However, neutrophils can also mediate tissue damage in various non-infectious … by releasing
pro-inflammatory mediators, including the cytokines interleukin (IL)-8 and IL-17, neutrophil

Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation

EM Martin, RL Till, MK Sheats… - Frontiers in veterinary …, 2017 - frontiersin.org
… cAMP activates two different intracellular pathways that mediate neutrophil adhesion,
protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac) (10, 11). …

The role of neutrophils in equine laminitis

B Leise - Cell and tissue research, 2018 - Springer
… This review will discuss the role of the neutrophil and neutrophil-associated mediators,
both systemically and locally, in the foot during the development of laminitis in the horse. …

Kinetics of equine neutrophil elastase release and superoxide anion generation following secretagogue activation: a potential mechanism for antiproteinase …

MP Dagleish, AD Pemberton, TJ Brazil… - Veterinary Immunology …, 1999 - Elsevier
… In conclusion these studies have shown that horse and human neutrophil elastase content
and mediator release functions are more closely matched than was previously thought. This …

The role of activated neutrophils in the early stage of equine laminitis

GR de Pouyade, D Serteyn - The Veterinary Journal, 2011 - Elsevier
… of neutrophils in laminar tissues in the induction of laminitis. Particular emphasis is placed
on the role of neutrophil … TNFα is a critical mediator of sepsis that contributes to organ …

Signaling mechanism for equine neutrophil activation by immune complexes

SL Jones, Y Sharief, CD Chilcoat - Veterinary Immunology and …, 2001 - Elsevier
Neutrophils (PMN) are critical host defense cells that have a role in the pathophysiology of a
… PMN, but not in equine PMN. We show here that adhesion of equine PMN to immobilized IC …