… Design of Therapy The first priority of treatment for advanced heart failure is relief of symptoms,
without which enthusiasm is limited for decreasing disease progression and prolonging …

… The therapeutic approach to heart failure begins … therapy with respectto both its monitoring
and adjustment. Diuretics remain a mainstay of therapy but, in the face of severe heart failure, …

… clinical characteristics of patients with advanced heart failure, (ii) inform physicians about
markers of poor prognosis that indicate an advanced stage of disease… to medical therapy alone …

… ventricular assist devices (LVAD) have emerged as the standard of care for advanced heart
failure … Evidence-based clinical management of LVAD-supported patients is becoming …

… Comprehensive heart failure management led to improved … to a heart failure program may
be appropriate not only for potential heart transplantation, but also for medical management of …

… with advanced heart failure, as described by a 2 × 2 table. Evaluation of clinical symptoms …
and may assist in selecting initial therapy and providing prognostic information. Although this …

… of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION) trial, 1520
patients with advanced heart failure … therapy or optimal pharmacological therapy plus cardiac …

… medical therapy, advanced pacemakers, and implantable defibrillators has changed prognosis
in heart failure (… respond poorly to standard therapy and develop chronic advanced HF.1, …

… •Moderate or severe heart failure, defined as symptomatic heart failure for at least 6 months
with NYHA Class III or IV symptoms at the … —Hospitalization for heart failure management …

… with heart failure have end-stage disease that is refractory to medical therapy (stage D heart
failure)… To identify evidence-based studies of palliative care in heart failure, we searched the …