The efficacy of first-line tyrosine kinase inhibitors combined with co-medications in Asian patients with EGFR mutation non-small cell lung cancer

VYF Su, KY Yang, TY Huang, CC Hsu, YM Chen… - Scientific reports, 2020 - nature.com
use may compromise the clinical efficacy of EGFR-TKIs in … co-medications use in patients
with NSCLC receiving EGFR-TKI … -medications use in NSCLC patients with EGFR mutations in …

… of gastric acid-suppressing medication use on the efficacy of erlotinib and gefitinib in patients with advanced non–small-cell lung cancer harboring EGFR mutations

Y Zenke, K Yoh, S Matsumoto, S Umemura, S Niho… - Clinical Lung Cancer, 2016 - Elsevier
… In this study, concurrent use of AS did not … EGFR mutations. It provides data that can guide
expectations for clinicians treating advanced NSCLC patients harboring EGFR mutations with …

Osimertinib in advanced EGFR-T790M mutation-positive non-small cell lung cancer patients treated within the Special Use Medication Program in Spain: OSIREX …

M Provencio, J Terrasa, P Garrido, RG Campelo… - BMC cancer, 2021 - Springer
… , including the EGFR Thr790Met (T790M) resistance mutation, MET amplification, … EGFR
T790M mutations have been detected in 48–62% of patients that develop resistance to EGFR

Effects of concomitant medication use on gefitinib‐induced hepatotoxicity

S Cho, J Yee, JY Kim, S Jeong Rhie… - The Journal of Clinical …, 2018 - Wiley Online Library
… with EGFR mutations.3, 4 Common toxicities of EGFR TKIs include skin rash, diarrhea, and
nausea, but most are mild in severity and manageable.3, 5 Severe hepatotoxicity involving …

Polypharmacy among older advanced lung cancer patients taking EGFR tyrosine kinase inhibitors

T Hakozaki, T Matsuo, A Shimizu, Y Ishihara… - Journal of Geriatric …, 2021 - Elsevier
… Potentially inappropriate medication (PIM) use was … analysis to identify factors affecting
multiple-medication use. … is significantly correlated with the BMI, EGFR mutation status, and GRIm-…

FDA- and EMA-Approved Tyrosine Kinase Inhibitors in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Safety, Tolerability, Plasma Concentration Monitoring …

I Solassol, F Pinguet, X Quantin - Biomolecules, 2019 - mdpi.com
… -TKIs are commonly used together with other types of medication that can substantially interact…
the performance therapy and prognosis of patients with advanced EGFR-mutated NSCLC. …

[HTML][HTML] Drug-drug interactions, safety, and pharmacokinetics of EGFR tyrosine kinase inhibitors for the treatment of non–small cell lung cancer

CR Kucharczuk, A Ganetsky… - Journal of the Advanced …, 2018 - ncbi.nlm.nih.gov
… For patients whose tumors have sensitizing EGFR mutations, EGFR tyrosine kinase … EGFR
TKIs and can encourage open communication with patients about concurrent medication use

Evaluation of Drug—Drug Interactions in EGFR-Mutated Non-Small-Cell Lung Cancer Patients during Treatment with Tyrosine-Kinase Inhibitors

M Occhipinti, M Brambilla, G Galli, S Manglaviti… - Journal of Personalized …, 2021 - mdpi.com
… the possibility to include the list of patient’s medications and to obtain a real-time profile
of … requiring medication, besides anticancer therapies. In addition, patients often use self-…

[HTML][HTML] EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction

NB Kumarakulasinghe, N Syn, YY Soon, A Asmat… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… AS are also widely used among the general population as over-the-counter medications
to … We identified patients who tested positive for known sensitizing EGFR mutations (EGFRmut …

Therapeutic strategies in EGFR mutant non-small cell lung cancer

HH Loong, SS Kwan, TS Mok, Y Lau - Current treatment options in …, 2018 - Springer
… treatment strategies in EGFR mutation positive NSCLC with a … Combination use of EGFR
TKIs with checkpoint inhibitors is … that required discontinuation of study medications [36•] (Table …