… The aim of this review is to present different features of medicinal chemistry as drug design,
… This review provides panoramic view to the medicinal chemists for supporting their efforts to …

… Interestingly, the history of Jak2 tyrosine kinase inhibitors extends back nearly two decades.
… Subsequent work demonstrated that AG490 also inhibited Jak2 tyrosine kinase activity and …

… through combinatorial chemistry, high-throughput screening, computational chemistry, and
traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs…

… Bruton’s tyrosine kinase (BTK). (8) … tyrosine kinase (TK) family; it is expressed in hepatocellular
carcinoma (HCC), interleukin 2 inducible T-cell kinase (ITK), resting lymphocyte kinase (…

… Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase in the Tec family, is a critical
effector molecule for B-cell development that has been identified as a validated target for B-…

… the chemistry, biological activity and clinical potential of new drugs with tyrosine kinase …
There are two main approaches to inhibit activity of oncogenic tyrosine kinases. The first strategy …

… tyrosine kinase inhibitors (MT-TKIs) as anticancer agents based on their chemical structures.
It … research field of medicinal chemistry, particularly for developing novel anticancer agents. …

… between these protein tyrosine kinases. These results demonstratethe ability to synthesize
selective tyrosine kinase inhibitors. The most potent EGF receptor kinase inhibitors also …

… A step-by-step molecular docking study was performed to show how designing five tyrosine
kinase inhibitors can advance pharmaceutical education in medicinal chemistry. Access to …

… Protein-tyrosine kinase Phosphotyrosine Inhibitor p56Ick … Protein-tyrosine kinases (PTKs)
were originally discovered … Exemplary of this process is the Laboratory of Medicinal Chemistry’…