… Mutations activate RET in a constitutive fashion which, in turn, results in aberrant stimulation
… RET in preclinical models of medullary thyroid carcinoma, and these models show that RET …

… Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function
mutations in the RET proto-oncogene. Associations between specific RET mutations (…

… distinct, dominantly inherited cancer syndromes. MEN 2A patients develop medullary thyroid
carcinoma (MTC) … In familial MTC, only the thyroid is affected. Germ-line mutations of the …

… Medullary thyroid carcinoma is a rare malignant tumor originating in parafollicular C cells. It
accounts for 5 to 8% of all thyroid … the involvement of the RET proto-oncogene in hereditary …

… the role of RET genetic screening for the … MEDULLARY THYROID carcinoma (MTC) originates
from parafollicular C cells and represents 5–10% of well-differentiated thyroid tumors (1–3)…

… To determine if RET mutations similar to those in MEN 2A … We found that 23% of sporadic
MTC had RET codon 9 I8 … in sporadic MTC; somatic mutation of RET codon 9 I8 appears to play …

… This reinforces the concept that RET may cooperate with … Medullary thyroid carcinoma
occurs in hereditary and sporadic forms. Figure 1 shows a summary of current knowledge of RET …

… the different RET mutations, we found 76.5% of RET 918 positive patients and 43% of RET
634 positive patients having nodes metastases. At variance, only 27% of RET negative cases …

… & Heitz, PU (1995) Analysis of RET protooncogene point mutations distinguishes heritable
from nonheritable medullary thyroid carcinomas. Cancer, 76, 479–489. Kosel, K. & Graeber, …

… 16 somatic mutations in MTC tumors A total of 57 archived medullary thyroid carcinoma …
RET protooncogene in sporadic medullary thyroid carcinoma. Genes, Chromosomes & Cancer. …