… BRAF inhibition and explore the safety of combination therapy with BRAF and MEK inhibition,
… 1 and 2 study to investigate the combination of the BRAF inhibitor dabrafenib and the MEK …

… survival of patients with BRAF V600 mutation–positive metastatic melanoma, as compared …
The combination of BRAF and MEK inhibition, as compared with single-agent BRAF inhibition…

… demonstrated that initial therapy with combined BRAF and MEK inhibition is more effective
in BRAF V600 -mutant melanoma than single-agent BRAF inhibitors. This study assessed the …

… to the approval of BRAF/MEK inhibitors (BRAF/MEKi) for BRAF V600 -mutant metastatic
melanoma, and we explore the three major effectors of BRAF/MEK inhibitor resistance which are …

… of the combination of BRAF plus MEK inhibitors compared with BRAF inhibitor monotherapy
… evidence for the mechanisms of resistance to combined therapy and assess future treatment …

… combined BRAF and MEK inhibition provided significant advantage in ORR, PFS and OS over
BRAF inhibition … combined BRAF and MEK inhibition will become the mainstay therapy for …

… When the short-term BRAF and MEK inhibitor therapy was combined … combination of BRAF
and MEK inhibitors with anti-PD-1 in patients with BRAF V600 -mutated metastatic melanoma…

… No head-to-head studies exist comparing BRAF inhibitor/MEK inhibitor (BRAFi/MEKi)
combination treatments for BRAF-mutant melanoma. A side-by-side analysis of randomized phase …

… together these data combining BRAF/MEK inhibitors with … melanoma progression on
BRAF/MEK inhibition may be too late. Even in cases where resistance to both BRAF/MEK inhibitors …

… melanoma treatments, including MAPK inhibitors. In this study of a large consecutive cohort
of metastatic melanoma patients treated with BRAF inhibitors … with MAPK inhibitors with 2-, 3-…