… but MEK2 escaped inhibition, allowing reactivation of ERK. Thus, MEK2 selectively …
inhibition by allosteric MEK inhibitors. The mechanism for selective MEK2 escape from inhibition …

… Like MEK inhibitors, GDC-0994 has broad activity in numerous … inhibition is likewise limited
by pathway reactivation. We therefore explored the concept of dual node suppression of MEK …

… in a large panel (n = 34) of KRAS-mutant cell lines, by measuring the reduction of phospho-MEK
… SHP2 and MEK inhibitors led to enhanced antiproliferative activity and MAPK pathway …

… pathway inhibition by standard MEK inhibitors. CH5126766 represents a new type of MEK
inhibitor that causes MEK … reactivation of RAF by conventional allosteric MEK inhibitors is …

… is the reactivation of multiple RTKs upstream of the MAPK pathway responsible for … pathways
by which they can promote cell signaling, and reactivation of RTKs following MEK inhibition …

… /MEK inhibitors (BRAF/MEKi) for BRAF V600 -mutant metastatic melanoma, and we explore
the three major effectors of BRAF/MEK inhibitor … pathway reactivation as the mechanism of …

… MEK inhibitor trametinib delivered by oral gavage daily suppressed MAPK pathway more …
Compared with either agent alone, combined BRAF V600E and MEK inhibitor treatment …

… MEK inhibitors in combination can override resistance to single agents 15 . We therefore
reasoned that combined RAF/MEK inhibition … the importance of this pathway in B-RAF(V600E) …

… MEK inhibition and frequent reactivation of RAF/MEK/ERK signaling as a mechanism of
resistance to BRAF inhibitor … BRAF and MEK inhibition. Because the combination of BRAF and …

… coexisting oncogenic pathways could negate the activity of MEK inhibitors, specifically the
PI3K–AKT pathway, which … As reactivation of MEK–MAPK signalling has been proposed as a …