MITF: master regulator of melanocyte development and melanoma oncogene

C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
… However, MITF also modulates the state of melanocyte … These data place MITF between
instructing melanocytes … MITF as a master lineage regulator in melanocyte development and its …

Epigenetic regulation during melanocyte development and homeostasis

R Dilshat, HN Vu, E Steingrímsson - Experimental Dermatology, 2021 - Wiley Online Library
… MITF is known as the master regulator of the melanocyte lineage and is a key for
melanoblast survival and specification (reviewed in 13 ). Mice homozygous for Mitf loss-of-function …

[PDF][PDF] Key discoveries in melanocyte development

A Kawakami, DE Fisher - J Invest Dermatol, 2011 - core.ac.uk
… of EDNRB signaling during melanocyte development, Shin et … is required for melanocyte
development between E10 and E12.… MITF is a master transcriptional regulator of the melanocyte

[HTML][HTML] The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

A Kawakami, DE Fisher - Laboratory investigation, 2017 - Elsevier
… insights into basic biology of pigmentation, melanocyte development, and melanoma. This
remarkable ‘Master Regulator' of the melanocyte lineage has key roles in both normal and …

[HTML][HTML] Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

GG McGill, M Horstmann, HR Widlund, J Du… - Cell, 2002 - cell.com
melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional
targets in primary melanocytes… , whose germline deletion produces melanocyte loss and which …

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

V Pogenberg, MH Ögmundsdóttir… - … & development, 2012 - genesdev.cshlp.org
… Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte
development and an important oncogene in melanoma. MITF heterodimeric assembly with …

The regulation of normal melanocyte proliferation

R Halaban - Pigment Cell Research, 2000 - Wiley Online Library
… are regarded as master regulators of the cell cycle governing the restriction (R) point, ie the
point of commitment from quiescence (G0/G1) to DNA synthesis (S) (129), by regulating the …

The melanocyte lineage in development and disease

RL Mort, IJ Jackson, EE Patton - Development, 2015 - journals.biologists.com
… The transcription factor microphthalmia-associated transcription factor (MITF) appears to be
the master regulator of melanocyte identity and is embedded within a transcriptional network …

OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

D Sheinboim, I Maza, I Dror, S Parikh… - Nature …, 2017 - nature.com
… MITF, SOX10, and PAX3 acquire melanocyte properties 19 . … Mitf master regulator in
differentiation promoting growth conditions in both somatic cells and pluripotent ESCs. We develop

Skin melanocytes: biology and development

M Cichorek, M Wachulska, A Stasiewicz… - … in Dermatology and …, 2013 - termedia.pl
… The most important growth factors regulating melanocyte development from the NCC are …
pathways are essential for melanoblast/melanocyte development. Studies in several model …