… show hydroxylated-biphenyl–curcumin derivatives as excellent “lead compounds” for the …
malignant melanoma. In fact, compared to the therapies currently used, these compounds have …

… and test new compounds with antiproliferative and cytotoxic activity on melanoma cells. We
… In conclusion this work demonstrates that the biphenyl eugenol-derivative enantiomer (S)-6,…

… parent compounds. Perillyl alcohol, a modulator of small G-protein activity, and biphenyl
compounds… A similar synergistic increase in the potency of each compound when ether-linked to …

… the experimental evidence that compound 1, a tetra-OMe biphenyl (D6 in … melanoma cells
with negligible effect on normal cells. A collection of eighteen derivatives of 1, compounds 2–…

… growth on primary MM cell lines. Material and … on MM cell lines to compare the antitumour
activity of both eugenol and curcumin to that of 11 related compounds (monomeric or biphenyl …

… Polychlorinated biphenyls (PCBs) are organic compounds containing from one to ten chlorine
atoms attached to a biphenyl … These compounds were classified in Group 1 on the basis of …

… melanoma, we treated the melanoma cell lines WM983-A, WM983-B, SK-MEL-5, WM852, and
WM1158 with a panel of diphenyl–pyrazole (DPP) compounds. … of DPP compounds, led to …

… biphenyl compound D6 (3E,3′E)-4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)…
of curcumin, exerts a strong antitumor activity on melanoma cells both in vitro and in vivo. …

… 1) against human melanoma cell line (A375) and to … such as cell viability (3(4,5-dimethylthiazol-2-yl)2,5-diphenyl-…
melanoma cells treated with this bibenzyl compound at 6. 25-12.5 μM. …

… biphenyl structure (an αβ unsaturated ketone called D6) whose antiproliferative and proapoptotic
activities on melanoma cell … part of melanoma cells response to D6 compound, being a …