Polyamine Depletion in Human Melanoma Cells Leads to G1 Arrest Associated with Induction of p21WAF1/CIP1/SDI1, Changes in the Expression of p21-regulated …
DL Kramer, BD Chang, Y Chen, P Diegelman, K Alm… - Cancer research, 2001 - AACR
… the cell cycle responses and cellular outcomes to polyamine depletion on MALME-3M
melanoma cells… The observed effects relate exclusively and directly to the depletion of polyamine …
melanoma cells… The observed effects relate exclusively and directly to the depletion of polyamine …
A novel polyamine-targeted therapy for BRAF mutant melanoma tumors
MC Peters, A Minton, O Phanstiel IV, SK Gilmour - Medical Sciences, 2018 - mdpi.com
… Our objective was to exploit the oncogene-induced polyamine transport activity in melanoma
cells by selectively … In general, polyamine depletion with DFMO treatment enhanced …
cells by selectively … In general, polyamine depletion with DFMO treatment enhanced …
… Analogue-induced Increases in Spermidine/Spermine N1-Acetyltransferase Activity, Polyamine Pool Depletion, and Growth Inhibition in Human Melanoma Cell …
CW Porter, B Ganis, PR Libby, RJ Bergeron - Cancer research, 1991 - AACR
… among melanoma cell lines, we have compared the cellular … cell lines. The results indicate
that the sensitivity of the MALME-3 cells may be related to a major perturbation of polyamine …
that the sensitivity of the MALME-3 cells may be related to a major perturbation of polyamine …
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells
Y Chen, DL Kramer, P Diegelman, S Vujcic, CW Porter - Cancer research, 2001 - AACR
… by 16 h and complete polyamine pool depletion by 20 h, both of … The data suggest that
SSAT induction, polyamine pool depletion, … and polyamine pool depletion), we used polyamine …
SSAT induction, polyamine pool depletion, … and polyamine pool depletion), we used polyamine …
Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells
K Käpyaho, R Sinervirta, J Jänne - Cancer research, 1985 - AACR
… phenotype by polyamine-depleted cells would result from … melanoma cells (25). Although
expression of differentiation markers, such an en hanced melanogenesis of melanoma cells or …
expression of differentiation markers, such an en hanced melanogenesis of melanoma cells or …
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in …
A Lentini, C Forni, B Provenzano, S Beninati - Amino acids, 2007 - Springer
… in B16-F10 melanoma cell line the possible effect of NG and HP in the modulation of the
activity of this enzyme. Figure 3 shows TGase activity of melanoma cells significantly enhanced, …
activity of this enzyme. Figure 3 shows TGase activity of melanoma cells significantly enhanced, …
Effect of Inhibition of Polyamine Biosynthesis by dl-α-Difluoromethylornithine on the Growth and Melanogenesis of B16 Melanoma in Vitro and in Vivo
PS Sunkara, CC Chang, NJ Prakash, PJ Lachmann - Cancer research, 1985 - AACR
… The objective of the present study was to investigate the effect of polyamine depletion by a-…
B16 melanoma cells grown in culture and also as solid tumors in mice. Polyamine depletion …
B16 melanoma cells grown in culture and also as solid tumors in mice. Polyamine depletion …
Polyamine Analogue Induction of the p53-p21WAF1/CIP1-Rb Pathway and G1 Arrest in Human Melanoma Cells
DL Kramer, S Vujcic, P Diegelman, J Alderfer, JT Miller… - Cancer research, 1999 - AACR
… is known to deplete polyamine pools by … in melanoma cells containing mt-p53. This is a
unique and obvious example of a positive gene response to polyamine analogues (or polyamines…
unique and obvious example of a positive gene response to polyamine analogues (or polyamines…
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells
Y Chen, K Alm, S Vujcic, DL Kramer, K Kee… - Cancer research, 2003 - AACR
… In SK-MEL-28 cells, exposure to DENSPM rapidly reduces the combined Spd and Spm …
of polyamine pool depletion in MAPK activation, we used dual polyamine inhibitors to deplete …
of polyamine pool depletion in MAPK activation, we used dual polyamine inhibitors to deplete …
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells
Y Chen, DL Kramer, F Li, CW Porter - Oncogene, 2003 - nature.com
… and ML-IAP as important determinants of polyamine analog drug action in melanoma cells.
… Briefly, maximum induction of SSAT and polyamine depletion take place by 16 h of treatment…
… Briefly, maximum induction of SSAT and polyamine depletion take place by 16 h of treatment…
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