… event after Tyr705 phosphorylation. In this study, the role and regulation … Ser727
phosphorylation in STAT3 in melanocytic cells were examined. STAT3 was phosphorylated on …

… ) is constitutively activated through Tyr705 phosphorylation in most melanoma cells. In this
… Ser727 phosphorylation in STAT3, another critical phosphorylation event, in melanoma cells …

… Analysis of STAT3 phosphorylation in the two melanoma cell … Ser 727 phosphorylation in
LU1205 cells but a relatively low level of Tyr 707 phosphorylation, which is required for STAT3 …

… in melanoma cells remains to be clarified. We have previously showed that the phosphorylation
of STAT3 at Ser727 in melanoma cells … frequently occur in melanoma cells (Davies et al. …

… that PKCδ and/or other isoforms are indeed implicated in STAT3 Ser727 phosphorylation
and growth inhibition by OSM. However, the relative implication of PKC isoforms appears to be …

… line was treated with two different doses of each inhibitor (10 and 25 μM) for 12 h and the
expression levels of STAT3 phosphorylated on Ser727 (Ser-STAT3), Tyr705 (Tyr-…

… , it has been shown that phosphorylation of STAT 1 and STAT 3 at serine residue by variety
of … C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific …

… The level of STAT3 remained relatively … of phosphorylated STAT3 at Tyr705 in SK-MEL-28
cells by western blot analysis. Instead, we observed that STAT3 phosphorylation on Ser727 …

… resistant cell lines showed a decrease in phospho-STAT3 Ser727 levels; therefore, the
regulation of this site alone does not explain the differential response of our melanoma cells to …

… the SH2 domain of STAT3 to inhibit its phosphorylation and dimerization. … melanoma cells
and display specificity for the Jak2-STAT3 pathway. FLLL32 and FLLL62 could inhibit STAT3 …