Regulating functional cell fates in CD8 T cells
PA Shrikant, R Rao, Q Li, J Kesterson, C Eppolito… - Immunologic …, 2010 - Springer
… For this review, we will focus on factors regulating type I effector and memory cell fate in
CD8 T cells, since type I associated cytokines have been shown to be necessary for antitumor …
CD8 T cells, since type I associated cytokines have been shown to be necessary for antitumor …
Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination
… Thus, the degree of inflammation, and therefore the amount of cytokines such as IL-12,
directs memory and effector CD8 + T cell fates via a graded expression of T-bet [26]. …
directs memory and effector CD8 + T cell fates via a graded expression of T-bet [26]. …
[HTML][HTML] Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
… in cell fates after division one leads to only 5%–20% of the clonal T cell burst entering the
memory T cell pool. … Molecular and functional profiling of memory CD8 T cell differentiation. …
memory T cell pool. … Molecular and functional profiling of memory CD8 T cell differentiation. …
[HTML][HTML] Defining memory CD8 T cell
MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
… compartment and classifications of memory CD8 T cell subsets with defined and discrete …
stable circulatory memory CD8 T cells are defined by the age of memory CD8 T cell (or time …
stable circulatory memory CD8 T cells are defined by the age of memory CD8 T cell (or time …
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells
S Tsuda, ME Pipkin - Cold Spring Harbor perspectives in …, 2022 - cshperspectives.cshlp.org
… in CD8 T cells, and the basic principles that underlie chromatin remodeling, transcription,
and cell fate … of naive CD8 T cells determines the development of memory cells might provide …
and cell fate … of naive CD8 T cells determines the development of memory cells might provide …
[HTML][HTML] Selected microRNAs define cell fate determination of murine central memory CD8 T cells
G Almanza, A Fernandez, S Volinia… - PloS one, 2010 - journals.plos.org
… Thus, our data suggest that cell fate determination in memory CD8 T cells operates
according to an expression gradient of specific microRNAs. This does not exclude a synergy …
according to an expression gradient of specific microRNAs. This does not exclude a synergy …
Memory CD8+ T cell differentiation
JJ Obar, L Lefrançois - Annals of the New York Academy of …, 2010 - Wiley Online Library
… Early cell fate determination model of effector and memory CD8 + T-… responding CD8 + T
cells to differentiation toward one cell fate or another: terminal effector cell or memory precursor. …
cells to differentiation toward one cell fate or another: terminal effector cell or memory precursor. …
[HTML][HTML] Transcriptional and epigenetic regulation of effector and memory CD8 T cell differentiation
… effector and memory T cells are formed is … of CD8 T cell differentiation upon acute infection,
with a focus on the transcriptional and epigenetic regulation of cell fate decision and memory …
with a focus on the transcriptional and epigenetic regulation of cell fate decision and memory …
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population
JJ Milner, H Nguyen, K Omilusik… - Proceedings of the …, 2020 - National Acad Sciences
… In connection, we refine paradigms of transcription factor-mediated regulation of memory T
cell fate. To date, T-bet (11), Blimp1 (15, 16), Zeb2 (17, 18), Stat4 (19), and Id2 (20–23) have …
cell fate. To date, T-bet (11), Blimp1 (15, 16), Zeb2 (17, 18), Stat4 (19), and Id2 (20–23) have …
The epigenetic control of stemness in CD8+ T cell fate commitment
L Pace, C Goudot, E Zueva, P Gueguen, N Burgdorf… - Science, 2018 - science.org
… memory T cell generation have been extensively analyzed, the impact of heterochromatin-dependent
gene expression silencing on the fates … of memory CD8 + T cell stemness, plasticity…
gene expression silencing on the fates … of memory CD8 + T cell stemness, plasticity…
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