… However, the KLRG1 Hi population is terminal, largely disappearing over the ensuing
weeks, whereas the Tmp cell population matures into long-term memory CD8 T cells ( …

… pathway in memory CD8 T cell differentiation is the focus of this article. Our initial finding of
differential Akt activation in CD25 HI and CD25 LO CD8 T cells that have disparate cell fates …

… CD8 + T cell exhibited distinct fates that were controlled by tissue-specific events. However,
memory CD8 + T cells … impinge upon CD8 + T cell fate was not a feature of these reports. …

… in which memory CD8 T cells originate from a subset of fate-permissive, activated CD8 T cells
… antigen has cleared but also re-express naive cell genes such as IL7R, BCL2 and CCR7. …

… of the memory CD8 T cell population, including antigen load, duration and strength of CD8
T cell stimulation, the level of inflammation, availability of CD4 T cell help and CD8 T cell …

… Our understanding of how effector CD8 + T cells adopt these different cell fates has grown
greatly in recent years. In this review, we discuss the transcriptional regulators that are known …

… CD8 T cells can differentiate into effector (T EFF ), memory (T MEM ), or exhausted (T EX )
CD8 T cells… and epigenetic changes that endow cells with different functional capacities and …

… infection, the time at which memory CD8 + T cells become endowed with the unique ability to
… in the regulation of terminal effector and memory cell fate decisions, it seems likely that this …

… They demonstrated that the degree of inflammation, and therefore the amount of cytokines
such as IL12, directs memory and effector CD8 + T-cell fates via a graded expression of T-bet. …

… functional qualities of the memory CD8 T cells, as memory cells with the phenotype (… memory
CD8 T cells to undergo homeostatic proliferation, a property essential for long-term memory …