[HTML][HTML] Polycystic ovary syndrome, affective symptoms, and neuroactive steroids: a focus on allopregnanolone

LR Standeven, E Olson, N Leistikow, JL Payne… - Current psychiatry …, 2021 - Springer
… a curvilinear relationship between testosterone levels and depression in women with and
without PCOS; ie, the most severe depression was associated with levels below and above the …

Serum allopregnanolone in women with postpartum “blues”

RE Nappi, F Petraglia, S Luisi, F Polatti, C Farina… - Obstetrics & …, 2001 - Elsevier
… We have recently shown that serum allopregnanolone levels … an interaction between
neurosteroids and the stress system,15, 17 … We found serum allopregnanolone levels lower than …

Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder

V Milivojevic, L Sullivan, J Tiber, N Fogelman… - …, 2023 - Springer
… of stress- and alcohol-cue provocation, we found that stress- … placebo increased plasma
levels of allopregnanolone in men … that increased levels of allopregnanolone were associated …

Lower allopregnanolone during pregnancy predicts postpartum depression: an exploratory study

LM Osborne, F Gispen, A Sanyal, G Yenokyan… - …, 2017 - Elsevier
… We measured second and third trimester (T2 and T3) progesterone (PROG) and
allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview …

Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology

R Cadeddu, M Van Zandt, LS Santovito… - …, 2023 - nature.com
stress exacerbates tic-like and other TS-associated responses via the neurosteroid
allopregnanolone … - a mild acute stressor that increases AP levels in the prefrontal cortex (PFC). …

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

RH Purdy, AL Morrow, PH Moore Jr… - Proceedings of the …, 1991 - National Acad Sciences
… Acute swim stress markedly increased allopregnanolone levels … in allopregnanolone returned
to baseline levels by 2 hr. … after stress, we measured progesterone and allopregnanolone

Neurosteroid levels in the orbital frontal cortex of subjects with PTSD and controls: a preliminary report

DA Cruz, LA Glantz, KD McGaughey, G Parke… - … Stress, 2019 - journals.sagepub.com
… with allopregnanolone levels 57 suggest that our findings of decreased levels of
allopregnanolone … not due to smoking and might actually underestimate the true levels in these …

The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause

A Kimball, LE Dichtel, MB Nyer, D Mischoulon… - …, 2020 - Elsevier
… women would have lower levels of progesterone and allopregnanolone but similar … for
effects of ambient stress are needed to establish normative levels of these neuroactive steroids …

Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis

ZK Qiu, GH Zhang, JL He, JC Ma, J Zeng, D Shen… - Neuroscience …, 2015 - Elsevier
allopregnanolone was associated with the symptoms of PTSD [20]. The down-regulation of
allopregnanolone … The lowered allopregnanolone levels in PTSD patients might contribute to …

[HTML][HTML] Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents

CE Marx, MJ VanDoren, GE Duncan… - …, 2003 - nature.com
… that olanzapine and clozapine would elevate allopregnanolone levels, but risperidone and
… in the stress response and serve as a precursor to adrenal GABAergic neurosteroids such as …