… control on CV outcomes. We did a meta-analysis with meta-regression to evaluate the
relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of CVOTs. …

… haemorrhagic); cardiovascular mortality (including deaths of unknown cause); and the
composite … of serious cardiovascular events previously used in a Merck-sponsored meta-analysis …

… that this meta-analysis provides valuable evidence concerning the risk for cardiovascular
events and death associated with nonselective NSAIDs. Our meta-analysis of randomized trials …

… study, 14 and was excluded from the meta-analysis. The CAFÉ Study 21 was excluded …
or AIx with CV events and all-cause mortality were deemed eligible for our meta-analysis 6–…

… cardiovascular events in our analysis were subjected to adjudication; sensitivity analysis
using adjudicated cardiovascular events … A third meta-analysis 24 conducted by FDA staff was …

… a cardiac event. • Dose effect relationship, ie the risk of developing a cardiovascular event
has … This could not be assessed in the present metaanalysis because of the lack of uniformity …

… The outcome of interest was the occurrence of a first fatal or non-fatal cardiovascular event.
In this meta-analysis, we defined fatal or non-fatal CVD as myocardial infarction, coronary …

… In addition to providing an overall estimate of risk, the tools of meta-analysis allow an …
We performed a meta-analysis of longitudinal studies that assessed any cardiovascular event …

… This pre-specified cardiovascular meta-analysis included all … The pre-specified primary
objective of this meta-analysis was … adverse cardiovascular events (MACE-4; cardiovascular …

… risk factor for cardiovascular events and could not be evaluated in this meta-analysis given
the sparse data. In conclusion, our meta-analysis provides evidence for an association of …