Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis

D Posthuma - Molecular psychiatry, 2018 - research.vu.nl
… the signal most strongly supported in this metaanalysis (best was rs9952159, P = 4.2 ×
10 … Among the other genes of interest, signals in or near PTPRD, which was previously …

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

…, MEta-analysis of type 2 DIabetes in African … - … genetics, 2014 - journals.plos.org
meta-analysis of 17 GWAS in 8,284 cases and 15,543 controls to explore the genetic architecture
of … in other populations due to differential genetic architecture across populations. Our …

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

SI Berndt, S Gustafsson, R Mägi, A Ganna, E Wheeler… - … genetics, 2013 - nature.com
Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

LC Tsoi, PE Stuart, C Tian, JE Gudjonsson… - Nature …, 2017 - nature.com
genetic architectureGenetic architecture and risk scores By increasing the number of
European-origin psoriasis susceptibility loci to 63, we were able to explore the genetic architecture

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

YR Li, J Li, SD Zhao, JP Bradfield, FD Mentch… - Nature medicine, 2015 - nature.com
Genome-wide association studies (GWASs) have identified hundreds of susceptibility genes,
including shared associations across clinically distinct autoimmune diseases. We …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis  … - … genetics, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …

Rice root genetic architecture: meta-analysis from a drought QTL database

B Courtois, N Ahmadi, F Khowaja, AH Price, JF Rami… - Rice, 2009 - Springer
… Following the development of molecular genetic approaches, the genetic architecture of
the rice root system has been extensively studied by teams interested in improving drought …

Revealing the genetic architecture of FHB resistance in hexaploid wheat (Triticum aestivum L.) by QTL meta-analysis

M Löffler, CC Schön, T Miedaner - Molecular Breeding, 2009 - Springer
Fusarium head blight (FHB) in wheat results in reduced yield and quality and in accumulation
of mycotoxins. The objective of this study was to identify genomic regions in wheat …

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

F Day, T Karaderi, MR Jones, C Meun, C He… - … genetics, 2018 - journals.plos.org
… Our data demonstrate that the genetic architecture does not differ based on the diagnostic
criteria used for PCOS. We also demonstrate a genetic pathway shared with male pattern …

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

JJ Tielbeek, E Uffelmann, BS Williams… - Molecular …, 2022 - nature.com
… estimates concerning the genetic overlap between personality and ASB. It seems worthwhile
to mention again here that partially overlapping genetic architectures do not provide causal …