PPARs: therapeutic targets for metabolic disease

JP Berger, TE Akiyama, PT Meinke - Trends in pharmacological sciences, 2005 - cell.com
… are potentially superior therapeutic agents for metabolic disease. These include dual
agonists of PPAR-α and PPAR-γ, which beneficially alter carbohydrate and lipid metabolism in a …

AMPK as a therapeutic target for treating metabolic diseases

EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
… In this review we evaluate the metabolic phenotypes of … this has on controlling lipid
metabolism, glucose homeostasis, and … -targeted therapeutics to treat chronic metabolic diseases. …

[HTML][HTML] PPARδ as a therapeutic target in metabolic disease

SM Reilly, CH Lee - FEBS letters, 2008 - Elsevier
… Therefore, PPARδ represents a novel therapeutic target and the development of PPARδ
gonists/modulators may be useful for treating the whole spectrum of metabolic syndrome. …

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

Y Cao - Nature reviews Drug discovery, 2010 - nature.com
… for selective therapeutic interventions. Anti-angiogenic agents can affect adipose metabolism
and … may be used for the treatment of metabolic diseases regardless of obesity. In addition, …

MANF: an emerging therapeutic target for metabolic diseases

Q Tang, Y Li, J He - Trends in Endocrinology & Metabolism, 2022 - cell.com
… some of these metabolic disturbances. In … metabolic disorders in obese mice. We therefore
propose that MANF might be a promising target for treating chronic metabolic diseases. …

Angiogenesis as a therapeutic target for obesity and metabolic diseases

Y Cao - Angiogenesis, Lymphangiogenesis and Clinical …, 2014 - karger.com
… an exciting opportunity for therapeutic interference of obesity and metabolic disease. In fact,
… body weights and metabolic rates of the host, implying a possible new therapeutic option for …

Gut microbiota as a therapeutic target for metabolic disorders

H Okubo, Y Nakatsu, A Kushiyama… - Current medicinal …, 2018 - ingentaconnect.com
… in turn influences host metabolism and disease phenotypes. Further … therapeutic target for
a range of metabolic disorders. … an early diagnostic marker and a therapeutic target for T2DM. …

PPARβ/δ: a key therapeutic target in metabolic disorders

X Palomer, E Barroso, J Pizarro-Delgado… - International journal of …, 2018 - mdpi.com
… skeletal muscle produces changes that resemble the effects of exercise training [61], making
it a potential candidate for mimicking the effects of exercise to treat metabolic diseases [62]. …

A promising therapeutic target for metabolic diseases: neuropeptide Y receptors in humans

M Yi, H Li, Z Wu, J Yan, Q Liu, C Ou… - Cellular Physiology and …, 2018 - karger.com
… the structural characteristics of human NPY receptors and their role in metabolic diseases. …
receptor represents an important diagnostic and therapeutic target for these types of cancer […

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - … and targeted therapy, 2023 - nature.com
metabolic diseases and pathological consequences, including diabetes, obesity, fatty liver
diseases… of proteins and pathways involved in metabolic diseases by focusing on PTM-based …