Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
… called metabolic memory. … epigenome-wide association studies might also inform precision
medicine approaches. Here, we highlight the emerging role of epigenetics and epigenomics …
medicine approaches. Here, we highlight the emerging role of epigenetics and epigenomics …
Epigenetic modifications in metabolic memory: What are the memories, and can we erase them?
Z Chen, R Natarajan - American Journal of Physiology-Cell …, 2022 - journals.physiology.org
… in metabolic memory. Hence, identification of epigenetic variations at candidate genes, or
epigenetic signatures genome-wide by epigenome-… and epigenomics in metabolic memory of …
epigenetic signatures genome-wide by epigenome-… and epigenomics in metabolic memory of …
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Z Chen, F Miao, AD Paterson… - Proceedings of the …, 2016 - National Acad Sciences
… referred to as metabolic memory. The mechanisms underlying metabolic memory are not
fully … evidence of a relationship between epigenetics and metabolic memory in human T1D. …
fully … evidence of a relationship between epigenetics and metabolic memory in human T1D. …
[HTML][HTML] Epigenetic mechanisms in diabetic complications and metabolic memory
MA Reddy, E Zhang, R Natarajan - Diabetologia, 2015 - Springer
… of epigenetics and epigenomics in the vascular complications of diabetes and metabolic
memory. … In the first report of epigenome profiling of patients with type 1 diabetes experiencing …
memory. … In the first report of epigenome profiling of patients with type 1 diabetes experiencing …
Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts
LK Park, AG Maione, A Smith, B Gerami-Naini… - Epigenetics, 2014 - Taylor & Francis
… Interpreting genome-wide epigenomic data relies on analyzing the interdependency of DNA
… In this study, we have identified the epigenomic landscape at the level of DNA methylation …
… In this study, we have identified the epigenomic landscape at the level of DNA methylation …
Epigenetic mechanisms in diabetic vascular complications and metabolic memory: The 2020 Edwin Bierman Award Lecture
R Natarajan - Diabetes, 2021 - Am Diabetes Assoc
… and metabolic memory directly in humans, we performed epigenomic profiling in white …
DCCT HbA 1c and experienced metabolic memory/microvascular complications during EDIC …
DCCT HbA 1c and experienced metabolic memory/microvascular complications during EDIC …
Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms
RV Intine, MP Sarras - Current diabetes reports, 2012 - Springer
… complications and the metabolic memory phenomenon. In fact, … phenomenon has been
termed, metabolic memory [25, 26]. … metabolic memory state) invokes a role for the epigenome in …
termed, metabolic memory [25, 26]. … metabolic memory state) invokes a role for the epigenome in …
Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes
F Miao, Z Chen, S Genuth, A Paterson, L Zhang… - Diabetes, 2014 - Am Diabetes Assoc
… In conclusion, we conducted comprehensive epigenomic profiling using cells from … metabolic
memory in individuals with type 1 diabetes. Our results suggest that this metabolic memory …
memory in individuals with type 1 diabetes. Our results suggest that this metabolic memory …
Understanding metabolic memory: a tale of two studies
RG Miller, TJ Orchard - Diabetes, 2020 - Am Diabetes Assoc
… termed “metabolic memory,” which implies altered metabolic … , we show that the metabolic
memory effect can be largely … Thus, there is no need for a concept like “metabolic memory” …
memory effect can be largely … Thus, there is no need for a concept like “metabolic memory” …
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms
S Tonna, A El-Osta, ME Cooper, C Tikellis - Nature Reviews …, 2010 - nature.com
… -up may confirm the existence of the phenomenon of 'metabolic memory'. However, the
attribution of these changes to 'metabolic memory' must be interpreted with caution as this study …
attribution of these changes to 'metabolic memory' must be interpreted with caution as this study …
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