New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages

A Batista-Gonzalez, R Vidal, A Criollo… - Frontiers in …, 2020 - frontiersin.org
macrophages were solely glycolytic and that FAO and OXPHOS were characteristic of
anti-inflammatory macrophages… for M2 macrophages, and FAO has been found to occur also in M1 …

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration

F De Santa, L Vitiello, A Torcinaro… - Antioxidants & redox …, 2019 - liebertpub.com
metabolic features, with a link between the metabolic pathways operating in MΦ and their
pro-/anti-inflammatory … will focus on the potentiality of manipulating metabolism to polarize MΦ. …

Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

V Lampropoulou, A Sergushichev, M Bambouskova… - Cell metabolism, 2016 - cell.com
… -inflammatory IL-1β-HIF-1α axis. Itaconate is one of the most highly induced metabolites in
activated macrophages… Here, we show that itaconate modulates macrophage metabolism and …

Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation

JD Bailey, M Diotallevi, T Nicol, E McNeill, A Shaw… - Cell reports, 2019 - cell.com
… involved in glucose metabolism. Our findings reveal a fundamental role for iNOS-derived
NO in … metabolic remodeling and cytokine production in the pro-inflammatory macrophage. …

Macrophages, meta‐inflammation, and immuno‐metabolism

H Shapiro, A Lutaty, A Ariel - The scientific world journal, 2011 - Wiley Online Library
… -metabolism explores the coregulation of energy metabolism … M1-skewed macrophages
are sustained in edematous, … macrophage phenotypes and impose distinct metabolic modes. …

Metabolic alterations in aging macrophages: ingredients for inflammaging?

AA Van Beek, J Van den Bossche… - Trends in …, 2019 - cell.com
… of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage
We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, …

Macrophages and the regulation of adipose tissue remodeling

G Martinez-Santibañez… - Annual review of …, 2014 - annualreviews.org
macrophages contribute to the remodeling events in lean and obese states. Advancing our
understanding of the involvement of macrophages in adipose tissue remodelingmetabolism. …

Contribution of metabolic reprogramming to macrophage plasticity and function

KCEL Kasmi, KR Stenmark - Seminars in immunology, 2015 - Elsevier
… component of chronic inflammatory conditions. Recent work demonstrates that inflammatory
macrophage activation is tightly associated with metabolic reprogramming to aerobic …

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

L Boutens, GJ Hooiveld, S Dhingra, RA Cramer… - Diabetologia, 2018 - Springer
… and trigger chronic low-grade inflammation, that promotes the … metabolism are currently
unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (…

The metabolic signature of macrophage responses

A Viola, F Munari, R Sánchez-Rodríguez… - Frontiers in …, 2019 - frontiersin.org
… is to discuss recent findings linking macrophage functions and metabolism. … macrophage
activation by inflammatory stimuli. Indeed, now we know that pro-inflammatory macrophages