[HTML][HTML] Tumor microenvironment and metabolic remodeling in gemcitabine‐based chemoresistance of pancreatic cancer

Z Gu, Y Du, X Zhao, C Wang - Cancer Letters, 2021 - Elsevier
Metabolic remodeling reduces GEM transport and synthesis in PDAC. This review focuses
… matrix (ECM), immune cells, and metabolic remodeling in the induction of GEM resistance; …

Crosstalk between metabolic remodeling and epigenetic reprogramming: A new perspective on pancreatic cancer

J Ren, B Ren, X Liu, M Cui, Y Fang, X Wang, F Zhou… - Cancer Letters, 2024 - Elsevier
… In this review, we aim to present the regulatory mechanisms of metabolic remodeling and …
of metabolism remodeling and epigenetic reprogramming crosstalk to pancreatic cancer

[HTML][HTML] Metabolism remodeling in pancreatic ductal adenocarcinoma

JT Li, YP Wang, M Yin, QY Lei - Cell Stress, 2019 - ncbi.nlm.nih.gov
Pancreatic cancer cells with KRAS mutation become dependent on non-oxidative PPP.
Consistently, KRAS knockdown decreases expression of enzymes that govern non-oxidative …

[HTML][HTML] Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism

T Shan, S Chen, X Chen, WR Lin, W Li… - Oncology …, 2017 - spandidos-publications.com
… studies, and the progression of pancreatic cancer was significantly affected after removing
… In conclusion, pancreatic CAFs remodeled the metabolic transition to reflect cancer cell …

[HTML][HTML] … transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer

X Li, Y Du, W Jiang, S Dong, W Li, H Tang, J Yi… - Frontiers in …, 2023 - frontiersin.org
metabolic status of pancreatic cancer, we performed metabolic analysis on tissue samples
from pancreatic cancer … The results showed the metabolic characteristics of PAAD progression …

[HTML][HTML] … heterogeneity in pancreatic cancer and pancreatic neuroendocrine tumor and its association with tumor immune microenvironment and metabolic remodeling

N Li, X Jia, Z Wang, K Wang, Z Qu, D Chi… - Frontiers in …, 2023 - frontiersin.org
pancreatic cancer (PC) and adjacent normal tissues based on the TCGA, GSE28735,
and GSE62452 datasets. We systematically explored the pan-cancer … of pancreatic cancer. …

… of pancreatic cancer cells reveals proteome-level effects of a novel combination drug therapy that induces cancer cell death via metabolic remodeling and activation of …

S Rasam, Q Lin, S Shen… - Journal of Proteome …, 2023 - ACS Publications
… could improve the efficacy of Gem-based treatment for pancreatic cancers. … in cancer cells.
(29) In this study, we quantified >5500 proteins with high data quality in pancreatic cancer

The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - National Acad Sciences
… In this study, we demonstrate that MUC1 oncogene regulates polyamine metabolism in
pancreatic cancer cells. The MUC1-mediated regulation of polyamine metabolism is governed by …

Pancreatic cancer metabolism: breaking it down to build it back up

RM Perera, N Bardeesy - Cancer discovery, 2015 - AACR
metabolism, such as diabetes and obesity. Finally, we discuss the translational potential of
exploiting knowledge about pancreatic cancer metabolism … maintenance or remodeling of the …

[HTML][HTML] Metabolism of pancreatic cancer: paving the way to better anticancer strategies

C Qin, G Yang, J Yang, B Ren, H Wang, G Chen… - Molecular cancer, 2020 - Springer
pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt
extensively distinct metabolic … Rewired glucose, amino acid and lipid metabolism and metabolic