… was associated with a reduction in ECM remodeling, epithelial-to-… in metabolic pathways
in TAMs. Taken together, our findings indicate that a global change in the activity of metabolic …

… In cancer cells, KRAS* activates glycolysis and glutamine flux to provide metabolic intermediates
for anabolic metabolism and to maintain redox homeostasis, respectively (5, 7). KRAS* …

… Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic … metabolic …

… Kras, CDE-mediated metabolic remodeling was described to be independent of Kras
mutation 100 . Collectively, these CAF-PCC metabolic crosstalk pathways further illustrate the …

… , and secrete factors that support ECM remodeling, cancer cell invasion, and metastasis. …
cancer metabolism, this acidic environment is largely induced by the secretion of metabolic end …

… transition were altered, suggesting tumour-like conditions promote metastatic 35 phenotypes
and metabolic remodeling. Using functional assays to validate RNA-seq data, we 36 …

KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo- …

… from the metabolism of normal cells, is called metabolic remodeling or … metabolic remodeling
and its importances from glycolysis metabolism and endogenous fatty acids metabolism in …

… In the original article, we reported that senescence-inducing therapies can induce vascular
remodeling that sensitizes pancreas cancers to chemo- and immunotherapies. We recently …

… pancreatic ductal adenocarcinoma, we identify the close association between the pancreatic
… In the orthotopic mouse model of pancreatic cancer, we identify the localized, graft-induced …