[HTML][HTML] Metformin reduces desmoplasia in pancreatic cancer by reprogramming stellate cells and tumor-associated macrophages
… was associated with a reduction in ECM remodeling, epithelial-to-… in metabolic pathways
in TAMs. Taken together, our findings indicate that a global change in the activity of metabolic …
in TAMs. Taken together, our findings indicate that a global change in the activity of metabolic …
Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer
… In cancer cells, KRAS* activates glycolysis and glutamine flux to provide metabolic intermediates
for anabolic metabolism and to maintain redox homeostasis, respectively (5, 7). KRAS* …
for anabolic metabolism and to maintain redox homeostasis, respectively (5, 7). KRAS* …
[HTML][HTML] The emerging roles of ATP-dependent chromatin remodeling complexes in pancreatic cancer
… Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic … metabolic …
dysregulation has been associated with the initiation and progression of pancreatic … metabolic …
[HTML][HTML] The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
Q Sun, B Zhang, Q Hu, Y Qin, W Xu, W Liu, X Yu… - Theranostics, 2018 - ncbi.nlm.nih.gov
… Kras, CDE-mediated metabolic remodeling was described to be independent of Kras
mutation 100 . Collectively, these CAF-PCC metabolic crosstalk pathways further illustrate the …
mutation 100 . Collectively, these CAF-PCC metabolic crosstalk pathways further illustrate the …
[HTML][HTML] Decoding the intricate landscape of pancreatic cancer: Insights into tumor biology, microenvironment, and therapeutic interventions
A Argentiero, A Andriano, IC Caradonna, G de Martino… - Cancers, 2024 - mdpi.com
… , and secrete factors that support ECM remodeling, cancer cell invasion, and metastasis. …
cancer metabolism, this acidic environment is largely induced by the secretion of metabolic end …
cancer metabolism, this acidic environment is largely induced by the secretion of metabolic end …
Tumour Microenvironment-Like Conditions Alter Pancreatic Cancer Cell Metabolism and Behaviour
GL Gardner, JA Stuart - American Journal of Physiology …, 2024 - journals.physiology.org
… transition were altered, suggesting tumour-like conditions promote metastatic 35 phenotypes
and metabolic remodeling. Using functional assays to validate RNA-seq data, we 36 …
and metabolic remodeling. Using functional assays to validate RNA-seq data, we 36 …
[HTML][HTML] Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer
KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo- …
response that promotes hypovascularity, immunosuppression, and resistance to chemo- …
[HTML][HTML] The molecular mechanism of metabolic remodeling in lung cancer
L Chang, S Fang, W Gu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
… from the metabolism of normal cells, is called metabolic remodeling or … metabolic remodeling
and its importances from glycolysis metabolism and endogenous fatty acids metabolism in …
and its importances from glycolysis metabolism and endogenous fatty acids metabolism in …
Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer
M Ruscetti, JP Morris, R Mezzadra, J Russell, J Leibold… - Cell, 2021 - cell.com
… In the original article, we reported that senescence-inducing therapies can induce vascular
remodeling that sensitizes pancreas cancers to chemo- and immunotherapies. We recently …
remodeling that sensitizes pancreas cancers to chemo- and immunotherapies. We recently …
[HTML][HTML] Lymphatic vessel remodeling and invasion in pancreatic cancer progression
… pancreatic ductal adenocarcinoma, we identify the close association between the pancreatic
… In the orthotopic mouse model of pancreatic cancer, we identify the localized, graft-induced …
… In the orthotopic mouse model of pancreatic cancer, we identify the localized, graft-induced …