… In this sense, CSCs have been reported to remodel the … not fully cover the metabolic needs
of pancreatic tumors due to … lead to a distinct metabolic program in pancreatic cancer cells …

… Repeated acute pancreatic injury and inflammation are important … pancreatic cancer. This
article attempts to understand the common pathways linking pancreatitis to pancreatic cancer. …

… In conclusion, the compounds designed in our study can remodel the tumor
microenvironment and are expected to be candidates for the treatment of pancreatic cancer. …

… The metabolic remodeling requires not only the adjustment of metabolic pathways per se
but … instructions, commanding the metabolic adaptation. Many diverse players are pivotal in …

… of glycolysis, is a metabolic node in cancer cells that can promote … Our study aims to sensitize
pancreatic cancer to anti PD-1 … as it targets specific metabolic pathways in cancer cells to …

… pancreatic cancer pathogenesis, including appreciation of precursor lesions or premalignant
pancreatic … from normal pancreatic tissue to invasive pancreatic cancer and identification of …

… and transitional process for pancreatic remodeling in response to intrinsic … metabolic
program may be an important player in pancreatic carcinogenesis. The relevance of metabolism …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United States
and in the world. Late diagnosis, early metastasis and lack of effective therapy are among …

… The recent discoveries in the field of genetics, biology, metabolism and immunology of
pancreatic cancer have created new opportunities to develop novel approaches for earlier …

… The tumour vasculature is disorganised and cannot sustain the metabolic needs of pancreatic
cancer growth. As a result PDAC is characterised by a hypoxic microenvironment where …