… component of the pancreatic cancer microenvironment, hyaluronic acid, provides an important
source of metabolic intermediates required for pancreatic cancer growth during conditions …

… The tumour vasculature is disorganised and cannot sustain the metabolic needs of pancreatic
cancer growth. As a result PDAC is characterised by a hypoxic microenvironment where …

… state, undergo a profound lipid metabolic shift during differentiation towards CAFs in
pancreatic cancer, thus promoting a growth permissive microenvironment for cancer cells (18). To …

… in pancreatic cancer (that is known to be heavily dependent on glutamine metabolism (39)),
we evaluated DON in pancreatic cancer … and clonogenicity in pancreatic cancer cells. It also …

… Aside from that, it has been found that the abundance of activated pancreatic stellate
cells in the stroma of pancreatic cancer can diminish NK cell functions in the local tumor …

… view of cell metabolism plasticity. Prior to discussing the molecular bases and the physiology
of metabolic remodeling, we provide below a rapid overview on cellular bioenergetics. …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most treatment refractory and lethal
malignancies. The diversity of endothelial cell (EC) lineages in the tumor microenvironment (…

… Human pancreatic cancer cell lines BxPC3 and PANC1 were obtained from the ATCC and
maintained according to the ATCC guidelines. Cells with low passage numbers (<20) were …

… in the TME of pancreatic cancer led to excessive remodeling of tumor extracelluar matrix, …
of genetics, metabolism, biology, and immunology of pancreatic cancer have brought new …

… the tumor stroma in pancreatic cancer. SPARC is overexpressed … involving impaired
gemcitabine metabolism due to reactive … in a GEMM of PDA that enzymatic remodeling of the ECM …