Metabolic competition in the tumor microenvironment is a driver of cancer progression

CH Chang, J Qiu, D O'Sullivan, MD Buck, T Noguchi… - Cell, 2015 - cell.com
… function, due to altered metabolism resulting from tumor-imposed glucose restriction. We
sought to establish whether glucose competition in the tumor microenvironment, in its own right, …

A novel strategy to fuel cancer immunotherapy: targeting glucose metabolism to remodel the tumor microenvironment

X Liu, Y Zhao, X Wu, Z Liu, X Liu - Frontiers in Oncology, 2022 - frontiersin.org
metabolism in tumor microenvironment, discussed the regulatory role of glucose metabolism
in … glucose metabolism to enhance the efficacy of cancer immunotherapy, especially ICIs. …

Metabolic cooperation and competition in the tumor microenvironment: implications for therapy

S Gupta, A Roy, BS Dwarakanath - Frontiers in oncology, 2017 - frontiersin.org
… This review focuses on the metabolic remodeling … the tumor cells, the T cells, and the
cancer-associated fibroblasts while discussing about the current strategies that target metabolism of …

Metabolism in the tumor microenvironment

AN Lau, MG Vander Heiden - Annual Review of Cancer Biology, 2020 - annualreviews.org
tumor microenvironment. Although there is a wide range of stromal cell types, here we discuss
the metabolism of four abundant types of stromal cells in tumors: … tumor microenvironment

Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor …

V Carito, G Bonuccelli, UE Martinez-Outschoorn… - Cell Cycle, 2012 - Taylor & Francis
metabolism in tumor-associated fibroblasts. Thus, MSF functions in the metabolic remodeling
of the tumor microenvironment … cancer-associated fibroblasts toward glycolytic metabolism. …

Metabolic remodeling in glioma immune microenvironment: intercellular interactions distinct from peripheral tumors

R Qiu, Y Zhong, Q Li, Y Li, H Fan - Frontiers in cell and …, 2021 - frontiersin.org
… This review will clarify the metabolic properties of glioma cells and their interactions with
tumor microenvironment immunity, and discuss the application strategies of metabolic therapy …

Metabolic hallmarks of tumor and immune cells in the tumor microenvironment

K Renner, K Singer, GE Koehl, EK Geissler… - Frontiers in …, 2017 - frontiersin.org
… , thereby facilitating tumor progression and metastasis. In this review, we describe the
metabolic interplay between immune cells and tumor cells and discuss tumor cell metabolism as a …

Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery

B Chen, A Gao, B Tu, Y Wang, X Yu, Y Wang, Y Xiu… - Biomaterials, 2020 - Elsevier
… therapy targeting tumor microenvironment via dual regulation on tumor metabolism and …
revealed their simultaneous modulation of tumor microenvironment. This work developed not …

Cross-talk between the tumor microenvironment, extracellular matrix, and cell metabolism in cancer

M Nazemi, E Rainero - Frontiers in oncology, 2020 - frontiersin.org
… cell metabolism. In this mini-review, we will describe how the tumor microenvironment and
cancer-associated fibroblasts dictate cancer cell metabolism, resulting in increased tumor

[HTML][HTML] Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

D Chen, X Zhang, Z Li, B Zhu - Theranostics, 2021 - ncbi.nlm.nih.gov
… from the tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-…
phenotypic and functional changes through metabolic connections. Numerous metabolites …