Iron metabolism in the tumor microenvironment—Implications for anti-cancer immune response

A Sacco, AM Battaglia, C Botta, I Aversa, S Mancuso… - Cells, 2021 - mdpi.com
… demand, thus affecting the tumor immunosurveillance. In this … metabolic pathways within
the tumor microenvironment and how this affects both tumor-associated macrophages and tumor

The acidic tumor microenvironment as a driver of cancer

E Boedtkjer, SF Pedersen - Annual review of physiology, 2020 - annualreviews.org
… In this review, we discuss how the acidity of the tumor microenvironment influences each …
The composition of the tumor microenvironment is dynamic, with blood flow and metabolism

The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities

CM Neophytou, M Panagi, T Stylianopoulos… - Cancers, 2021 - mdpi.com
… aberrations are predominantly responsible for tumor initiation and progression [1], it has
become clear during the last two decades that the tumor microenvironment (TME) plays an …

[HTML][HTML] Targeting metabolic remodeling in glioblastoma multiforme

A Wolf, S Agnihotri, A Guha - Oncotarget, 2010 - ncbi.nlm.nih.gov
… to oncogenic signaling pathways or the tumor microenvironment are potential mechanisms
resulting in the deregulation of metabolic enzymes with ensuing metabolic modification. …

Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance

M Tajaldini, A Poorkhani, T Amiriani, A Amiriani… - European Journal of …, 2023 - Elsevier
… The goal of the study is to target physical barriers, reduce mechanical stress, and limit
mechano-metabolic activation related to fibroblast/fibrosis remodeling by concentrating on …

The tumor microenvironment in colorectal cancer therapy

L Pedrosa, F Esposito, TM Thomson, J Maurel - Cancers, 2019 - mdpi.com
… of changing tumor microenvironments over the course of tumor … As pointed out above,
cancer metabolism and its tight … We also speculate that the metabolic reprogramming of tumor

Targeting tumor metabolism: a new challenge to improve immunotherapy

S Kouidhi, F Ben Ayed… - Frontiers in …, 2018 - frontiersin.org
… A deeper understanding of key mechanisms generating an immunosuppressive tumor
microenvironment (TME) remains a major challenge for more effective antitumor immunity. There …

Remodeling metabolic fitness: Strategies for improving the efficacy of chimeric antigen receptor T cell therapy

L Shen, Y Xiao, J Tian, Z Lu - Cancer Letters, 2022 - Elsevier
… malignancies, which is not yet met in solid tumors. The efficacy of CAR-T therapy is … in
tumor microenvironment (TME), which is closely correlated with T cell metabolism fitness. …

Characterization of the tumor microenvironment and tumor–stroma interaction by non-invasive preclinical imaging

N Ramamonjisoa, E Ackerstaff - Frontiers in oncology, 2017 - frontiersin.org
… coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment.
Int J Biochem Cell Biol (2011) 43(7):1045–51. doi:10.1016/j.biocel.2011.01.023 …

Tumor and its microenvironment: a synergistic interplay

V Catalano, A Turdo, S Di Franco, F Dieli… - Seminars in cancer …, 2013 - Elsevier
… Cancer cells exacerbate the oxidant microenvironment by enhanced basal metabolic … of
brain tumor xenografts by expanding the CSCs pool. Thus, tumor microenvironment orchestrates …