… how targeting metabolic vulnerabilities in prostate cancer may … metabolic vulnerabilities
characterizing PCa initiation and progression. The link between driver oncogenes and metabolic …

… These vulnerabilities may be exploited with mechanistically novel … in reprogramming prostate
cancer metabolism. … monitoring the metabolic dependencies of prostate cancer subtypes. …

… to categorize metabolic … metabolic profiles of four prostate cancer cell lines with varying
degrees of aggressiveness. We observed metabolic differences between the aggressive prostate …

… a critical metabolic conduit linking cytosolic and mitochondrial metabolism, is transcriptionally
regulated by AR. Experimental MPC inhibition restricts proliferation and metabolic outputs …

… features, androgen receptor signaling, genetic drivers in prostate cancer, and the … metabolic
interactions) to identify metabolic vulnerabilities. We explore the links between metabolism …

… We discuss how tackling PCa metabolic vulnerabilities represents a potential approach of
synthetic lethality to endocrine therapies. Finally, we describe how the continuous advances in …

… cancer-specific metabolic vulnerabilities, we have developed a novel pipeline to build spatially
resolved metabolic network models for prostate cancer … We identified metabolic genes …

… findings, we test for potential actionable metabolic vulnerabilities by targeting Cav-1-mediated
lipid scavenging and metabolism in a mouse model of aggressive prostate cancer. …

… To study the impact of pharmacological compounds on the metabolic potential of prostate
cancer cells, we treated PNT1A, LNCaP, C4-2, and PC-3 cells with ARN, IACS and assessed …

… genes and hormonal regulation of metabolic pathways in prostate cancer (PCa). Head-arrow …
Moreover, PTEN null cells showed a higher vulnerability to the inhibition of mitochondria …