… about the pharmacokinetics of oxymatrine (OMT) and its metabolite matrine (MT) after iv …
established for the determination and pharmacokinetic study of OMT and its metabolite MT in …

… sensitive enough for detecting the metabolite MT in plasma. … metabolite MT after topical
application of OMT up until now. … is described to determine OMT and its active metabolite MT in …

… unambiguous identification and quantification of oxymatrine and its active metabolite matrine
in … a meaningful basis for evaluating the clinical applications of the oxymatrine oral solution. …

… quantification of oxymatrine (OMT) and its metabolite matrine (MT) … spectrometric (LC–ESI-MS)
analysis. Extend-C18 column (2.1 mm … Linear detection responses were obtained for OMT …

… Oxymatrine (OMT) and matrine (MT), primarily effective and toxic ingredients that are well-known
target markers of radix S. tonkinensis [3], [4], [5], [6], [7], [8], have been found to have anti…

… -like alkaloids whose main constituents are oxymatrine and its active metabolite matrine,
which are known as bioactive materials against various insect pests, pathogenic fungi, bacteria, …

… to the absorption and metabolism of quinolizidine alkaloids, … pharmacokinetic studies of
matrine, oxymatrine and oxysophocarpine … , investigation of the metabolism of multi quinolizidine …

… Further studies should be undertaken to determine whether matrine and oxymatrine can
affect … matrine or oxymatrine with the drug metabolized by CYP2E1 and CYP3A. Although …

… This indicates that oxymatrine may be converted to matrine in the GI tract. After absorption,
matrine is distributed to … Oxymatrine and matrine were then determined separately as follows. …

… determination of plasma concentration of lamivudine, oxymatrine and its active metabolite
matrine … single oral co-administration of 5.0 mg kg)1 lamivudine and 30.0 mg kg)1 oxymatrine. …