… We report on the response of the human plasma metabolome to common preanalytical
variations in a comprehensive metabolomics analysis to reveal such high-quality markers. …

… In conclusion, there are significant differences in the metabolite profiles of serum and … this
period have a significant impact on the metabolite profile of plasma. Almost all large clinical …

… [24] reported none of the additives introduced any additional variation in the MS-derived
metabolomic profiles, but concluded that studies should not compare plasma prepared with …

… In summary, our data show pronounced changes in various metabolites from different
metabolite groups due to pre-storage handling at RT. Increases in concentrations are especially …

… on potential seasonal differences in metabolite profiles. The differences we observed in …
different seasons of blood draw might reflect seasonal variation in diet or other exposures, such …

… Fasting, according to clinical regulations, is recommended before sample collection,
because the metabolite profile in blood undergoes dynamic changes during a period of several …

… However, they also highlighted that centrifugation at higher speeds provoked significant
changes in metabolomic profiles, probably due to cell breakage. Accordingly, the protocol …

… and quantification of hundreds to thousands of primary compounds and metabolites in a single
… In this study, circadian variation was found to be especially important for newborns profile …

… metabolite profiling approach to discover biomarkers suitable as QIs for the pre-analytical …
already reported, metabolite ratios that might be well suited as pre-analytical QIs. Among …

… Additionally, variation coefficients were found in the range between 4 and 30%. Hence, the
… appropriate for the identification of relative concentration differences between defined study …