Metabolomic profiling of the aqueous humor in patients with wet age-related macular degeneration using UHPLC–MS/MS

G Han, P Wei, M He, H Teng, Y Chu - Journal of proteome …, 2020 - ACS Publications
… Assessing metabolomic alterations in age-related macular degeneration (AMD) can provide
insights into its pathogenesis. We compared the metabolomic profiles of the aqueous humor …

Plasma metabolomic profiles associated with three-year progression of age-related macular degeneration

I Lains, K Mendez, A Nigalye, R Katz, VP Douglas… - Metabolites, 2022 - mdpi.com
retinal function with dark adaptation (DA). Fasting plasma samples were also collected for
metabolomic profiling. … In conclusion, plasma metabolomic profiles are associated with clinical …

Metabolome-wide association study of neovascular age-related macular degeneration

MP Osborn, Y Park, MB Parks, LG Burgess, K Uppal… - PloS one, 2013 - journals.plos.org
metabolic profiling can detect metabolic differences between NVAMD patients and controls
in a discovery cohort. The results of this work may lead to a better understanding of AMD …

A plasma metabolomic profiling of exudative age-related macular degeneration showing carnosine and mitochondrial deficiencies

JM Chao de la Barca, B Rondet-Courbis… - Journal of Clinical …, 2020 - mdpi.com
metabolomic profile of exudative age-related macular degeneration (AMD), we performed a
targeted metabolomics study … involved in the plasma metabolomic profile of exudative AMD, …

Metabolomics in age-related macular degeneration: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2020 - iovs.arvojournals.org
… revealed six new metabolites involved in the plasma metabolomic profile, suggesting
mitochondrial energetic impairments and carnosine deficiency might play a role in NVAMD. Han et …

Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers

I Laíns, RS Kelly, JB Miller, R Silva, DG Vavvas, IK Kim… - Ophthalmology, 2018 - Elsevier
… of metabolomics for … metabolomic profiles of participants with neovascular AMD and those
of a control group. The current study aimed to characterize the plasma metabolomic profiles of …

Human plasma metabolomics in age-related macular degeneration: meta-analysis of two cohorts

I Laíns, W Chung, RS Kelly, J Gil, M Marques, P Barreto… - Metabolites, 2019 - mdpi.com
analysis of MS plasma metabolomic profiles from a large group of patients with AMD, and a
group of subjects older than 50 years with normal macula … the plasma metabolomic profiles of …

Metabolomics and age-related macular degeneration

CN Brown, BD Green, RB Thompson, AI Den Hollander… - Metabolites, 2018 - mdpi.com
… It should be noted that tears used in this study were obtained from patients with dry eye
syndrome [179] and so their metabolomic profiles and relative metabolite concentrations may …

Plasma metabolomics of intermediate and neovascular age-related macular degeneration patients

SL Mitchell, C Ma, WK Scott, A Agarwal… - Cells, 2021 - mdpi.com
… In conclusion, this study demonstrates that the plasma metabolic profiles of IAMD patients
are more similar to controls than to NVAMD patients. These results suggest that when …

[HTML][HTML] Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK consortium

IE Acar, L Lores-Motta, JM Colijn, MA Meester-Smoor… - Ophthalmology, 2020 - Elsevier
… In the current study, we performed the largest metabolomics analysis in AMD to date,
including 2307 AMD patients and 4294 control individuals from 5 cohorts. Using an NMR-based …