… -modified composite scaffolds can effectively promote bone defect healing… metal ions in the
treatment of bone defects, this paper reviews the mechanism of metal ions in promoting bone …

… of metal ions in different stages of maxillofacial development and pathological defects healing,
… and find the significant role of metal ions in the treatment of maxillofacial bone defects. …

… Releasing biologically active elements like Ti, Cu, Co, Sr, Li, Mo, and Zn from these biomaterials
has been observed to aid bone defect regeneration, stimulate angiogenesis, enhance …

… activity, various kinds of metal ion-doped HA-based … review of metal ion-doped HA-based
materials for bone defect … , and applications of different kinds of metal ion (Ag + , Zn 2+ , Mg 2+ , …

… , Mg 2+ , and Ca 2+ ions, named processed pyritum hydrogel (PPH). … metal ion clusters in
bone regeneration, PPH has been shown to regulate a variety of genes in the process of bone …

… Hence, this paper aims to review the currently available bone grafts and bone substitutes
as well as the biological and bio-inorganic factors for the treatments of bone defect. …

… To provide an overview of the regenerative potential of the different metal ions… bone formation
were assessed in a murine bone defect healing model; aside from an enhanced total defect…

… of clinical treatment of bone defect repair in detail. The advantages and disadvantages of bone
tissue … The doping of metal ions or bioactive ions opens a new avenue for the utilization of …

… bone defects more efficiently, we must consider the anatomical location of the bone defect, …
, the state of the body, and whether the defect is combined with metabolic diseases [7]. …

… , self-control studies were excluded because metallic ions from both experiment and
control groups may influence each other in terms of their effects on bone defects repair [22,50]. …