Metal sensing by the IRT1 transporter-receptor orchestrates its own degradation and plant metal nutrition

G Dubeaux, J Neveu, E Zelazny, G Vert - Molecular cell, 2018 - cell.com
… Soil iron uptake uses the broad metal spectrum IRT1 transporter that also transports zinc, …
acts as a transporter and receptor (transceptor), directly sensing excess of its non-iron metal

The bifunctional transporterreceptor IRT 1 at the heart of metal sensing and signalling

V Cointry, G Vert - New Phytologist, 2019 - Wiley Online Library
… direct sensing of non-iron metals flowing through IRT1 to drive its degradation. We propose
that transporters that also act as receptors … transport by sensing local nutrient concentrations. …

[HTML][HTML] Metal transporters and metal sensors: how coordination chemistry controls bacterial metal homeostasis

Z Ma, FE Jacobsen, DP Giedroc - Chemical reviews, 2009 - ncbi.nlm.nih.gov
metal transporters and metal sensor proteins are known to exploit specific coordination
chemistries of metal-ligand complexes to “select” a cognate metal or metal … “metal receptor

Coordination chemistry of bacterial metal transport and sensing

Z Ma, FE Jacobsen, DP Giedroc - Chemical reviews, 2009 - ACS Publications
metal transporters and metal sensor proteins are known to exploit specific coordination
chemistries of metal−ligand complexes to “select” a cognate metal or metal … “metal receptor

A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport

M Hershfinkel, A Moran… - Proceedings of the …, 2001 - National Acad Sciences
… heavy metals. Furthermore, zinc failed to activate the Ca 2+ -sensing receptor heterologously
… Zinc ions also specifically bind to many membrane receptors, transporters, and channels, …

Differential metal sensing and metal‐dependent degradation of the broad spectrum root metal transporter IRT1

J Spielmann, V Cointry, F Devime, S Ravanel… - The Plant …, 2022 - Wiley Online Library
… Moreover, the high Cd concentration also reduced the plasma membrane level of the
brassinosteroid receptor BRI1, which is not related to metal homeostasis (Figure S3b,c). We …

Cellular sensing and transport of metal ions: implications in micronutrient homeostasis

AJ Bird - The Journal of nutritional biochemistry, 2015 - Elsevier
… of genes encoding metal transporters affect intracellular metal ion levels. … how metal ions
are sensed, the types of domains that can be use to sense metal levels, where in a cell sensing

Metal sensor proteins: nature's metalloregulated allosteric switches

DP Giedroc, AI Arunkumar - Dalton Transactions, 2007 - pubs.rsc.org
… with the formation of “metal receptor” complexes of exquisite … structural features of metal
sensing coordination complexes … 28 metal transporter systems and conservatively, ≈15 metal

Understanding how cells allocate metals using metal sensors and metallochaperones

S Tottey, DR Harvie, NJ Robinson - Accounts of Chemical …, 2005 - ACS Publications
transporters and metal-storage proteins, act in … metals to proteins. Here, we consider the
ArsR−SmtB family but acknowledge the existence of other families of bacterial metal sensors

The roles of calcium-sensing receptor (CaSR) in heavy metals-induced nephrotoxicity

AA Kosiba, Y Wang, D Chen, CKC Wong, J Gu, H Shi - Life sciences, 2020 - Elsevier
… , it was observed the metal impaired the function of insulin… metals or some drugs can induce
toxicity in the kidney through a disruption in intracellular Ca 2+ signaling and ion transporters