Treatment of patients with metastatic colorectal cancer and poor performance status: current evidence and challenges

LSS Rocha, RP Riechelmann - Clinics, 2018 - SciELO Brasil
… with metastatic colorectal cancer and poor performance status… Eastern Cooperative Oncology
Group performance status ≥2. … metastatic colorectal cancer patients with poor performance

Real-world treatment and outcomes of metastatic colorectal cancer patients with a poor or very poor performance status

A Travers, A Jalali, S Begbie, C Semira… - … Colorectal Cancer, 2021 - Elsevier
… for patients with metastatic cancer. Patients with a poor performance status represent a …
of up to 41% of routine care metastatic colorectal cancer (mCRC) patients presenting with …

… analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer

DJ Sargent, CH Köhne, HK Sanoff, BM Bot… - Journal of Clinical …, 2009 - ascopubs.org
Performance status (PS) is a prognostic factor in patients with metastatic colorectal cancer.
Clinical trials typically enroll less than 10% of patients with a PS of 2 (PS2); thus, the benefit of …

Effects of palliative chemotherapy in unresectable or metastatic colorectal cancer patients with poor performance status

LS da Silva Rocha, CMV Moniz, MPM e Silva… - … Colorectal Cancer, 2023 - Elsevier
… In the present study, palliative multiagent chemotherapy in poor performance status patients
with non-molecularly selected colorectal cancer tended to impact tumor symptoms control; …

The effects of palliative chemotherapy in metastatic colorectal cancer patients with an ECOG performance status of 3 and 4

MC Teixeira, DF Marques, AC Ferrari, MFS Alves… - … colorectal cancer, 2015 - Elsevier
… of patients with metastatic colorectal cancer (… performance.2, 3, 4 Currently we have scarce
data to evaluate whether such benefits apply equally to patients with poor performance status

[HTML][HTML] Prognostic impact of performance status on the outcomes of immune checkpoint inhibition strategies in patients with dMMR/MSI-H metastatic colorectal cancer

G Mazzoli, R Cohen, S Lonardi, F Corti, E Elez… - … Journal of Cancer, 2022 - Elsevier
… We investigated Eastern Cooperative Oncology Group performance status in 502 patients
with mismatch repair deficient/ microsatellite instability-high metastatic colorectal cancer

Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status

MC Mormont, AM Langouët, B Claustrat… - Chronobiology …, 2002 - Taylor & Francis
… Four rhythms known to reflect circadian clock function were studied in 18 patients with
metastatic colorectal cancer and good performance status. Rest–activity was monitored by wrist …

… /activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status

MC Mormont, J Waterhouse, P Bleuzen… - Clinical cancer …, 2000 - AACR
… with histologically proven metastatic colorectal cancer, referred for chronomodulated
chemotherapy, were registered in the study; 52% of the patients had two or more metastatic sites, …

A phase II trial of frontline capecitabine and bevacizumab in poor performance status and/or elderly patients with metastatic colorectal cancer

A Naeim, PR Ward, HJ Wang, R Dichmann… - Journal Of Geriatric …, 2013 - Elsevier
… In this study, patients (pts) who were frail (ECOG 2) or older patients with ECOG 1 performance
status (PS) received CAP (1000 mg/m 2 bid, 14 days of every 21 days) plus BEV (7.5 mg/…

[HTML][HTML] … and performance status on treatment efficacy and safety of cetuximab plus irinotecan in irinotecan-refractory elderly patients with metastatic colorectal cancer

CF Jehn, L Böning, H Kröning, A Pezzutto… - … Journal of Cancer, 2014 - Elsevier
… for median overall survival in metastatic colorectal cancer [21]. In … population with a good
performance status, rather reflecting … for treatment of advanced metastatic cancer. Importantly, …