CD95/Fas and metastatic disease: What does not kill you makes you stronger

JP Guégan, C Ginestier, E Charafe-Jauffret… - Seminars in cancer …, 2020 - Elsevier
… Novel inhibitors targeting the pro-inflammatory roles of CD95/CD95 L may provide … or
cancer. This review discusses the roles of the CD95/CD95 L pair in cell migration and metastasis. …

[HTML][HTML] Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis

P Terheyden, C Siedel, A Merkel, E Kämpgen… - Journal of investigative …, 1999 - Elsevier
… study using primary tumors and subsequently evolving metastatic lesions. Patients’ … in
two primary tumors and six metastatic lesions; hence, the percentage of positive lesions

Prognostic relevance of altered Fas (CD95)‐system in human breast cancer

M Mottolese, S Buglioni, C Bracalenti… - … journal of cancer, 2000 - Wiley Online Library
… of metastatic lymph nodes and larger tumor size while Fas … Patients with Fas positive
tumors exhibited longer disease-… of Fas were significantly related to the presence of metastatic

Fas/CD95 signaling rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer

H Onodera, A Mori, S Nagayama, A Fujimoto… - … of colorectal disease, 2005 - Springer
… the determination of Fas/CD95 signaling along with the number of metastases may be a
useful prognostic factor for patients undergoing resection of colorectal liver metastases. These …

Expression of Fas ligand (CD95L) in primary malignant melanoma and melanoma metastases is associated with overall survival

K Neuber, B Eidam - Oncology Research and Treatment, 2006 - karger.com
… of Fas (CD95) as well as FasL (CD95L) expression in primary malignant melanoma and
melanoma metastases … , FasL/CD95L and Fas/CD95 expression in neither primary tumors nor …

CD95/Fas, non-apoptotic signaling pathways, and kinases

M Le Gallo, A Poissonnier, P Blanco… - Frontiers in …, 2017 - frontiersin.org
… breast cancer or SLE, in whom it contributes to disease severity by activating non-apoptotic
signaling pathways and promoting either metastatic … Here, we discuss the roles of CD95 in …

Expression of FAS (CD95/APO‐1) and FAS ligand in lung cancer, its prognostic and predictive relevance

R Koomägi, M Volm - International journal of cancer, 1999 - Wiley Online Library
… non-metastatic or only slightly metastatic cancer cells. Our results show that reduced Fas
and FasL expression might contribute to tumor progression or metastasis in human NSCLC. …

Soluble Fas (CD95) is a prognostic factor in patients with metastatic breast cancer undergoing high-dose chemotherapy and autologous stem cell transplantation

M Bewick, M Conlon, AM Parissenti, H Lee… - … of Hematotherapy & …, 2001 - liebertpub.com
Fas (sFas) are associated with a number of different disease states and with tumor progression
and metastasis … of sFas in 94 women with metastatic breast cancer undergoing high-dose …

Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver

H Li, X Fan, C Stoicov, JH Liu, S Zubair, E Tsai… - Gastroenterology, 2009 - Elsevier
cancer specimens show alterations in the CD95 (Fas Ag/Fas L) pathway as tumors progress
from local to metastatic disease, … a role in invasive behavior of colon cancer. However, direct …

Prognostic relevance of Fas (APO-1/CD95) ligand in human colorectal cancer

KM Sheehan, DG O'Donovan… - European journal of …, 2003 - journals.lww.com
Fas/Fas ligand system in the escape of gastrointestinal cancers has been implicated, particularly
in colorectal cancer… correlates with distant metastases and unfavourable outcome [ 19 ]. …