3-Phenyl-5-methyl-2H, 5H-furan-2-ones: tuning antifungal activity by varying substituents on the phenyl ring

M Pour, M Špulák, V Balšánek, J Kuneš… - Bioorganic & medicinal …, 2000 - Elsevier
… aimed to prepare compounds with various substituents with different electronic influence
on … out, we designed a series of simple 5-methyl derivatives 5. We envisaged an easy, high-…

An efficient substituent dependent synthesis of congested pyridines and pyrimidines

R Pratap, B Kumar, VJ Ram - Tetrahedron, 2007 - Elsevier
… Numerous methods are reported for the construction of pyridines by varying substitution …
of the positive inductive effect of the methyl substituent of acetamidine, which hinders the …

Synthesis and Anti-HIV-1 Activity of 4, 5, 6, 7-Tetrahydro-5-methylimidazo [4, 5, 1-jk][1, 4] benzodiazepin-2 (1H)-one (TIBO) Derivatives. 3

HJ Breslin, MJ Kukla, DW Ludovici… - Journal of Medicinal …, 1995 - ACS Publications
varying substitution at the N-6 site, evaluating the pure enantiomers related to the 5-Me
substituent… at the C-5 site of 1, where a methyl group resided in our original lead compounds. The …

Structure and substituent effect on chiral separation of some 4a‐methyl‐2, 3, 4, 4a‐tetrahydro‐1H‐fluorene derivatives and 4a‐methyl‐1, 2, 3, 4, 4a, 9a‐hexahydro …

C Roussel, C Suteu, L Shaimi, M Soufiaoui - Chirality, 1998 - Wiley Online Library
methyl are classical substituents in QSAR studies, so it was interesting to see which set of
substituent … the chlorine between methyl and fluorine and much closer to methyl. In most …

Steric effect of di-lateral methyl substituent on the mesophase behavior of four-ring azo/ester/azo homologues

AA Fahmi, GR Saad, MH Ali, NHS Ahmed - Liquid Crystals, 2022 - Taylor & Francis
… of varying long terminal flexible substituent, polarity of compact terminal and lateral substituents
… Terminal substituents are known to affect the polarity and polarisability of the aromatic …

Novel azoester compounds with a lateral methyl substituent

S Dixit, RA Vora - Molecular Crystals and Liquid Crystals, 2014 - Taylor & Francis
vary from 15 to 95C and the smectic phase lengths vary … to presence of the lateral methyl
group lowered its mesophase … due to the lateral methyl substituent their solid to mesomorphic …

… transformations of small-ring heterocyclic compounds. 99. 1, 4-Substituent shifts in the photorearrangement of 2-hydroxymethyl-2H-azirine derivatives to N …

A Padwa, PHJ Carlsen, A Tremper - Journal of the American …, 1978 - ACS Publications
… Electron-withdraw-ing substituents in the para position were found to facilitate the
rearrangement while electron-donating groups retard the 1, 4-substituent shifts. Both the sign and …

Quantitative estimation of steric effects. III. Substituent constants and steric contributions to chemical shifts of methyl group protons in ring iodinated methylbenzenes

JG Lindberg, A Leong - Journal of Magnetic Resonance (1969), 1975 - Elsevier
… of methyl group protons attributable to the presence of ortho, meta, and para iodine atoms
and methyl … A table is presented summarizing the generally useful substituent constant data …

Substituent interactions in slow-inverting aziridines

DJ Anderson, DC Horwell, RS Atkinson - Journal of the Chemical …, 1971 - pubs.rsc.org
… these aziridines with methyl iodide.2 When the three substituents in (Ia) + (Ib) are varied, any
… aziridine C-substituent and an N-substituent is large in comparison with that between a C-…

Substituent and solvent effects on the UV/Vis absorption spectra of 5-(4-substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones

GS Ušćumlić, DZ ˇ Mijin, NV Valentić, VV Vajs… - Chemical Physics …, 2004 - Elsevier
substituents on the absorption spectra of arylazo pyridone dyes. For quantitative assessment
of the substituent … The molecular extinction coefficients (ε max ) vary from 20 000 to 40 000 …