过去一年中添加的文章,按日期排序

CBP Expression Contributes to Neuropathic Pain via CREB and MeCP2 Regulation in the Spared Nerve Injury Rat Model

CC Lee, KB Park, MS Kim, YD Jeon - Medicina, 2024 - mdpi.com
3 天前 - … Background and Objectives: This study aimed to investigate the relationship
between neuropathic pain and CREB-binding protein (CBP) and methyl-CpG-binding protein 2 (…

m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis

J Zhang, H Li, LA Niswander - Nature Communications, 2024 - nature.com
6 天前 - … Rncr3 conserved exons 2/3 are cytosine methylated and bound by methyl-CpG
binding protein MeCP2, which restricts expression of miR124a embedded in exon 4 to prevent …

[HTML][HTML] Potentiation of the muscarinic acetylcholine receptor 1 modulates neurophysiological features in a mouse model of Rett syndrome

HW Dong, K Weiss, K Baugh, MJ Meadows… - …, 2024 - Elsevier
6 天前 - … Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by
mutations in the X chromosome-linked gene Methyl-CpG Binding Protein 2 (MECP2). Restoring …

[HTML][HTML] Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode

Y Yang, L Xu, S Zhang, L Yao, Y Ding, W Li… - Journal of Biological …, 2024 - Elsevier
9 天前 - methyl-CpG binding domain 3 isoform C (MBD3C) interacts specifically with the
histone H3 binding protein WD repeat-containing protein … ) derived from the MBD3C protein at a …

[PDF][PDF] Proteomic analysis of MeCP2 patient serum reveals arginine biosynthesis pathway was affected in p. Lys254* variation

T Wang, J He, X Peng - techrxiv.org
14 天前 - … MeCP2 is a DNA binding protein which involved in higher order chromatin organization,
RNA splicing, mutations in Mecp2 affect virtually all organs and tissues[2],also include …

Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice

Y Feng, J Wang, J Liu, Y Zhou, Y Jiang, W Zhou, F Wu… - Cells, 2024 - mdpi.com
15 天前 - Methyl-CpG-binding protein 2 (Mecp2) is an epigenetic modulator and numerous
studies have explored its impact on the central nervous system manifestations. However, little …

[HTML][HTML] Abolished clustering of MeCP2T158M can be partially reverted with small molecules

R Lata, L Steegmans, R Kellens… - Translational …, 2024 - transmedcomms.biomedcentral.com
16 天前 - … Rett syndrome (OMIM 312750) is a rare neurodevelopmental disorder caused
by de novo mutations in the Methyl-CpG Binding Protein 2 (MeCP2) gene located on the X-…

Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome

E Audouard, N Khefif, B Gillet-Legrand, F Nobilleau… - Pharmaceutics, 2024 - mdpi.com
18 天前 - … Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation
in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously expressed …

[HTML][HTML] Nodding syndrome: A role for environmental biotoxins that dysregulate MECP2 expression?

PS Spencer, RV Angues, VS Palmer - Journal of the Neurological Sciences, 2024 - Elsevier
19 天前 - … This initially pediatric brain disease, which has some clinical overlap with Methyl-CpG-binding
protein 2 (MECP2) Duplication Syndrome, has impacted certain impoverished …

… projection cell and parvalbumin interneuron architecture increases epileptic susceptibility in mouse model of methyl CpG binding protein 2 duplication syndrome

J Ge, S Xie, J Duan, B Tian, P Ren, E Hu, Q Huang… - …, 2024 - Wiley Online Library
20 天前 - Objective Methyl CpGbinding protein 2 (MECP2) duplication syndrome is a rare X‐linked
genomic disorder affecting predominantly males, which is usually manifested as …