… -timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA
methylation marks can be used as clocks in cells where ongoing methylation and demethylation …

… Here, we define a “DNA methylation clock” as an estimator built from epigenetic DNA methylation
… These DNA methylation clocks are generally built with a supervised machine learning …

… methylation age measures the cumulative effect of an epigenetic maintenance system. This
novel epigenetic clock … the patient from whom the cancer cell line was derived (Additional file …

… collections of individual methylation sites whose aggregate methylation status measures
chronological age, referred to as the DNA methylation clock. DNA methylation may also have …

… in PD, using epigenetic mitotic aging and aging clocks. Here, we aimed to define the
influence of blood cell lineage on epigenetic mitotic age and then investigate mitotic age …

… -tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian
clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, …

… clock contribute to age-related DNA methylation changes… Cell composition is a major
confounding factor for epigenetic studies, as cell lineage is a major determinant of DNA methylation…

… The multi-tissue DNA methylation-based (DNAm) age estimator (blue line), also known as
Horvath’s clock, stands out in terms of its correlation with chronological age across multiple …

… Large-scale population studies must also account for the now well-documented effects of
age on a subset of DNA methylation loci, the so-called Horvath clock CpG loci (Horvath 2013), …

… Curiously, the three hypermethylation-based clocks estimated that IMR90, a cell line
initially derived from fetal lung fibroblasts that has been extensively cultured, had a replicative …