The prognostic value of MGMT promoter methylation in glioblastoma: a meta‐analysis of clinical trials

MM Binabaj, A Bahrami, S ShahidSales… - Journal of cellular …, 2018 - Wiley Online Library
… methyltransferase (MGMT) is suggested to … patients with glioblastoma (GBM). Therefore,
we evaluated the associations between MGMT promoter methylation and prognosis of patients

Personalized treatment strategies in glioblastoma: MGMT promoter methylation status

N Thon, S Kreth, FW Kreth - OncoTargets and therapy, 2013 - Taylor & Francis
… In the older glioblastoma patient, MGMT promoter methylation status is on the verge of
entering clinical decision making. Combined chemoradiotherapy comprising temozolomide might …

The prognostic value of MGMT promoter methylation in Glioblastoma multiforme: a meta-analysis

K Zhang, X Wang, B Zhou, L Zhang - Familial cancer, 2013 - Springer
MGMT promoter methylation in patients with GBM. Although the findings of two studies [21,
37] which reported the status of MGMT promoter methylation … of MGMT promoter methylation

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly

…, M Weller, German Glioma Network - … journal of cancer, 2012 - Wiley Online Library
… that specifically patients with MGMT promoter methylated tumors … trial, patients with MGMT
promoter methylation had longer … A predictive effect of MGMT promoter methylation for PFS …

Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

S Everhard, J Tost, H El Abdalaoui, E Crinière… - Neuro …, 2009 - academic.oup.com
patients according to MGMT promoter methylation in future GBM trials without further indication
about MGMT … clear survival benefit in GBM patients with a methylated MGMT promoter, 4 …

The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas

TY Jung, S Jung, SG Jin, KS Moon, IY Kim… - …, 2009 - journals.lww.com
… was significantly associated with an increased overall survival in comparison to survival
in patients in whom MGMT promoter methylation was not detected. With respect to the …

Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM

N Shah, B Lin, Z Sibenaller, T Ryken, H Lee, JG Yoon… - PloS one, 2011 - journals.plos.org
… To best identify the specific MGMT promoter region most predictive of gene … the methylation
status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

M Weller, R Stupp, G Reifenberger… - Nature Reviews …, 2010 - nature.com
… anaplastic glioma patients with MGMT promoter methylation, … patients whose tumors showed
MGMT promoter methylation, … that MGMT is involved in the repair of radiation-induced DNA

Prognostic Value of Three Different Methods of MGMT Promoter Methylation Analysis in a Prospective Trial on Newly Diagnosed Glioblastoma

A Christians, C Hartmann, A Benner, J Meyer… - PloS one, 2012 - journals.plos.org
… recommend pyrosequencing for analyses of MGMT promoter methylation in high-throughput …
MGMT promoter status for patients suffering from malignant glioma, promoter methylation of …

MGMT promoter methylation and glioblastoma prognosis: a systematic review and meta-analysis

Y Chen, F Hu, Y Zhou, W Chen, H Shao… - Archives of medical …, 2013 - Elsevier
patients with MGMT promoter methylation had significant OS and PFS advantage than those
without methylated … In conclusion, patients with MGMT promoter methylation had significant …