… MHC alleles partly due to the lack of statistically significant number of known peptides in the
commonly studied length … algorithm is based on peptides of flexible lengths and sequence-…

… length and the magnitude of structural shift. The sole exception is CDR3β of the KB5-C20
TCR, which, at a length … CDR3β, show no relationship between loop length and structural shift. …

… for the MHC, it seemed reasonable to assume that TCRs can adapt to and recognize peptides
of a different length … Such peptide length flexibility would further maximize the ability of the …

… peptides of flexible lengths and trained by using more diverse sets of non-binders. MHC-BPS
is a web-based MHC… for predicting peptide binders of flexible lengths for 18 MHC class I …

… peptides to the peptide-binding region. Knowledge of the accessible states of the empty
MHC class I molecules and characterization of flexible … to bind an antigenic peptide and may …

… molecules reveals an elegant solution to the multiple constraints of flexible but stable binding,
with the ligand … The lengths of peptides bound to class I MHC molecules do, however, vary; …

… protein, we perform 20,000 independent, flexible-backbone peptide docking simulations. …
outward from the two canonical anchor positions (P 2 and P 9 for a peptide of length nine). …

… length preference of MHC-specific binding peptides. … flexible docking methods cannot be
directly applied to the prediction of peptide-MHC binding, mainly because the binding peptides …

… conformational dynamics, ie, the flexibility, of the binding site that is altered upon peptide …
, and class I binds to low-affinity peptides (with sequences or lengths that slightly diverge from …

… We suggested that an extension of this length might protrude out of the MHC class I binding
site [… This illustrates the flexibility of the otherwise apparently closed binding cleft of the class I …