… MHC class I molecules. In this Review, we bring this into context with the current understanding
of the general MHC class I antigen … of MHC class I and class II antigen presentation …

… individuals, must generate peptides for MHC class I molecules which,because of their …
only scant amounts of antigen. Degradationof cytosolic antigens and generation of MHC class I–…

… MHC class I molecules may be loaded with peptides derived from extracellular proteins in a
process called MHC class … pathways operating in classical MHC class I presentation and has …

… Here we review the cell biological aspects of antigen presentation through the eyes of …
antigen processing pathways for presentation by MHC class I (MHC-I) and MHC class II (MHC-II) …

… antigen-presenting cells (APC) as major regulatory cells in the acquired immune response.
MHC class II-restricted antigen … protein antigens and the site of peptide binding to MHC class …

… and MHC-like chaperones that support the MHC class I and II … We now understand that
the MHC system shapes both the … outs of MHC class I and MHC class II antigen presentation. …

… Their different subunits, ie, low-molecular-mass polypeptides (LMPs), are involved in the
efficiency of proteosome functions to produce antigenic peptides capable of binding MHC class …

… of MHC class II molecules is to bind peptides derived from antigens that access the endocytic
route of antigen … Formation of the MHC II–peptide complexes entails the confluence of the …

… Exogenous antigens are internalized by antigen-presenting … Generated peptides are then
loaded onto MHC class II (MHC-… are generated from endogenous antigens by degradation …

… , MHC class I molecules present endogenous antigens to … presentation of exogenous antigens
by MHC class I molecules. … by which exogenous antigens access MHC class I molecules. …