… DM action still remain unanswered, and this constrains our ability to integrate these advances
into deeper understanding of how DM … HLA-DM-mediated catalysis of MHC-II peptide …

… peptides do not interact with DM. ► Dissociation of the peptide N-terminus from the MHC
groove is required for DM … Key principles of peptide loading are similar between MHC class I …

… I MHC molecules, which bind peptides derived from cytosolic antigens and present them to
CDB-restricted T cells, class II MHC molecules generally bind peptides … these peptides to …

… HLA-DM, the catalytic action of HLA-DM on class II peptide loading is inhibited. HLA-DO
thus affects the peptide repertoire that is eventually presented to the immune system by MHC …

… peptide-receptive conformation. The crystal structure of a MHC class II–HLA-DM complex
explains how HLA-DM … rapid peptide exchange process that favors the highest-affinity ligands. …

… class II molecule that is quantitatively associated to HLA-DM In a subpopulation of APCs, …
of HLADM. Thus, HLA-DM and HLA-DO controi the composition of the peptide repertoire …

… We first evaluated whether DM facilitates peptide binding by stabilizing empty MHC II … ,
with DM, or with peptide, in each case at 37C overnight in buffer with endosomal pH. If DM were …

… DM susceptibility were seen for different peptides binding to the same MHCII allele as well as
for one peptide … peptide sequence and MHC polymorphism in controlling DM susceptibility. …

… However, MHCII peptide loading is impacted by other mechanisms including antigen …
of MHCII peptide loading by the accessory molecules HLA-DM (DM) and HLA-DO (DO) (2). …

… In the absence of a crystal structure for the DM-MHC-II complex, … of the MHC-II-peptide
interaction, and on studies of the DM-MHC-… for the mechanism of DM mediated peptide catalysis. …